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Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs.
Argonaute proteins associate with small RNAs that guide mRNA degradation, translational repression, or a combination of both. The human Argonaute family has eight members, four of which (Ago1 throughExpand
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Identification of microRNAs of the herpesvirus family
Epstein-Barr virus (EBV or HHV4), a member of the human herpesvirus (HHV) family, has recently been shown to encode microRNAs (miRNAs). In contrast to most eukaryotic miRNAs, these viral miRNAs doExpand
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Identification of Tissue-Specific MicroRNAs from Mouse
MicroRNAs (miRNAs) are a new class of noncoding RNAs, which are encoded as short inverted repeats in the genomes of invertebrates and vertebrates. It is believed that miRNAs are modulators of targetExpand
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A uniform system for microRNA annotation.
MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented forExpand
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Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability.
RNA-binding proteins coordinate the fates of multiple RNAs, but the principles underlying these global interactions remain poorly understood. We elucidated regulatory mechanisms of the RNA-bindingExpand
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Identification of Novel Argonaute-Associated Proteins
RNA silencing processes are guided by small RNAs known as siRNAs and microRNAs (miRNAs) . They reside in ribonucleoprotein complexes, which guide the cleavage of complementary mRNAs or affectExpand
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Splicing of precursors to mRNAs by the spliceosomes
An elastic supporting surface for beds, divans, arm-chairs and the like, and a method of producing such surface, comprising preparing a particular chemical composition suitable to form rubber-likeExpand
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The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. melanogaster Homolog Are Required for miRNA Biogenesis
MicroRNAs (miRNAs) represent a family of small noncoding RNAs that are found in plants and animals (for recent reviews, see ). miRNAs are expressed in a developmentally and tissue-specific manner andExpand
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siRNAs: applications in functional genomics and potential as therapeutics
Molecules that can specifically silence gene expression are powerful research tools. Much effort has been put into the development of such molecules and has resulted in the creation of differentExpand
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Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing.
A large number of miRNAs have recently been discovered in plants and animals. Development of reverse genetic approaches that act to inhibit microRNA function would facilitate the study of this newExpand
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