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Organotin Compounds and Selected Metals in the Marine Environment of Northern Adriatic Sea
TLDR
Mussels, as accumulators of pollutants, in general contained higher metal concentrations during winter time in Dockyard Izola, and metals in sediments exhibited elevated concentrations in Marina Portorož and Dockyards Izola. Expand
Pleurotus and Agrocybe hemolysins, new proteins hypothetically involved in fungal fruiting.
TLDR
Ostreolysin is expressed during formation of primordia and fruiting bodies, in accord with previous finding that the Aa-Pri1 gene is specifically expressed during fruiting initiation, suggestive that the isolated hemolysins play an important role in initial phase of fungal fruiting. Expand
Interaction of ostreolysin, a cytolytic protein from the edible mushroom Pleurotus ostreatus, with lipid membranes and modulation by lysophospholipids.
TLDR
The inhibitory effect of lysophospholipids may reflect a regulatory role for these components on the physiological action of ostreolysin and related proteins during fruiting. Expand
Cytolytic proteins from cnidarians - an overview.
TLDR
The physiological relevance of membrane permeabilization is described, and basic data on those proteinaceous cnidarian cytolysins proven or presumed to damage cell membranes by pore formation are presented. Expand
Characterization of anticholinesterase-active 3-alkylpyridinium polymers from the marine sponge Reniera sarai in aqueous solutions.
TLDR
It is found that biologically active polymers are composed of head-to-tail 3-alkylpyridinium units, which are soluble only in water, while low molecular oligomers are readily soluble in organic solvents. Expand
Biological activities of aqueous extracts from marine sponges and cytotoxic effects of 3-alkylpyridinium polymers from Reniera sarai.
TLDR
3-alkypyridinium polymers isolated from Reniera sarai were hemolytic and strongly cytotoxic against different cell lines with slightly expressed specificity against transformed cells. Expand
A new cytolytic protein from the sea anemone Urticina crassicornis that binds to cholesterol- and sphingomyelin-rich membranes.
TLDR
The presence of both sphingomyelin and cholesterol, key components of lipid rafts, greatly enhances toxin binding to membranes and probably facilitates pore formation in a new pore-forming cytolytic protein isolated from the Northern red sea anemone, Urticina crassicornis. Expand
APS8, a Polymeric Alkylpyridinium Salt Blocks α7 nAChR and Induces Apoptosis in Non-Small Cell Lung Carcinoma
TLDR
It is shown that APS8 inhibits NSCLC tumor cell growth and activates apoptotic pathways, and was not toxic for normal lung fibroblasts, suggesting thatAPS8 or similar compounds might be considered as lead compounds to develop antitumor therapeutic agents for at least certain types of lung cancer. Expand
A new phospholipase A2 isolated from the sea anemone Urticina crassicornis - its primary structure and phylogenetic classification.
TLDR
The isolation and characterization of a PLA(2) from the northern Pacific sea anemone, Urticina crassicornis (UcPLA(2), containing a C27N substitution and a truncated C-terminal sequence is reported, finding that Asn27-'type' PLA( 2)s are present in a few other marine animal species, including some vertebrates. Expand
Primary and secondary structure of a pore-forming toxin from the sea anemone, Actinia equina L., and its association with lipid vesicles.
TLDR
It is proposed that at least part of the alpha-helix content increase of equinatoxin II is due to the insertion of its N-terminus into the lipid bilayer, which shares structural homology with membrane active peptides like melittin and viral fusion peptides. Expand
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