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Defining the Epithelial Stem Cell Niche in Skin
Many adult regenerative cells divide infrequently but have high proliferative capacity. We developed a strategy to fluorescently label slow-cycling cells in a cell type–specific fashion. We used this… Expand
Socializing with the Neighbors Stem Cells and Their Niche
The potential of stem cells in regenerative medicine relies upon removing them from their natural habitat, propagating them in culture, and placing them into a foreign tissue environment. To do so,… Expand
Distinct self-renewal and differentiation phases in the niche of infrequently dividing hair follicle stem cells.
- Y. Zhang, J. Cheong, Nichita Ciapurin, D. McDermitt, T. Tumbar
- Medicine, Biology
- Cell stem cell
- 4 September 2009
In homeostasis of adult vertebrate tissues, stem cells are thought to self-renew by infrequent and asymmetric divisions that generate another stem cell daughter and a progenitor daughter cell… Expand
Quantitative proliferation dynamics and random chromosome segregation of hair follicle stem cells
- Sanjeev K. Waghmare, Rajat Bansal, Jayhun Lee, Y. Zhang, D. McDermitt, T. Tumbar
- Biology, Medicine
- The EMBO journal
- 7 May 2008
Regulation of stem cell (SC) proliferation is central to tissue homoeostasis, injury repair, and cancer development. Accumulation of replication errors in SCs is limited by either infrequent division… Expand
Defining the cellular lineage hierarchy in the inter-follicular epidermis of adult skin
The interfollicular epidermis regenerates from heterogeneous basal skin cell populations that divide at different rates. It has previously been presumed that infrequently dividing basal cells known… Expand
Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation
Aml1/Runx1 controls developmental aspects of several tissues, is a master regulator of blood stem cells, and plays a role in leukemia. However, it is unclear whether it functions in tissue stem cells… Expand
Defining a tissue stem cell‐driven Runx1/Stat3 signalling axis in epithelial cancer
Cancers and tissue stem cells (SCs) share similar molecular pathways for their self‐renewal and differentiation. The race is on to identify unique pathways to specifically target the cancer, while… Expand
Runx1 Directly Promotes Proliferation of Hair Follicle Stem Cells and Epithelial Tumor Formation in Mouse Skin
- Charlene S L Hoi, S. Lee, +6 authors T. Tumbar
- Biology, Medicine
- Molecular and Cellular Biology
- 22 March 2010
ABSTRACT Runx1/AML1 is a transcription factor implicated in tissue stem cell regulation and belongs to the small Runx family of cancer genes. In the hair follicle (HF), Runx1 epithelial deletion in… Expand
Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments
Runx1 controls timing of adult HSFC and short-term progenitor emergence in the embryonic epithelium and HFSC differentiation and long-term skin integrity in embryonic mesenchyme.
Hairy tale of signaling in hair follicle development and cycling.
Hair follicles (HFs) is an appendage from the vertebrate skin epithelium, and is critical for environmental sensing, animal appearance, and body heat maintenance. HFs arise from the embryonic… Expand