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Selection of a carbohydrate-binding domain with a helix-loop-helix structure.
We obtained a novel carbohydrate-binding peptide having a helix-loop-helix scaffold from a random peptide library. The helix-loop-helix peptide library randomized at five amino acid residues wasExpand
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Antibody-catalyzed removal of the p-nitrobenzyl ester protecting group: the molecular basis of broad substrate specificity.
Antibody catalysts for the removal of the p-nitrobenzyl ester protecting group have been generated to accommodate a broad range of substrates. Antibody 7B9, which was elicited against p-nitrobenzylExpand
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Catalytic antibodies induced by a zwitterionic hapten.
A zwitterionic hapten 4 featuring both positively and negatively charged functional groups was designed and synthesized with the goal of generating catalytic antibodies for the hydrolysis of ester 6Expand
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Strained‐Ring and Double‐Bond Systems Consisting of the Group 14 Elements Si, Ge, and Sn
The organometallic chemistry of the Group 14 elements E = Si, Ge, Sn in the 1980's is highlighted by the successful construction and characterization of three systems previously thought to be tooExpand
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Concise synthesis of ciguatoxin ABC-ring fragments and surface plasmon resonance study of the interaction of their BSA conjugates with monoclonal antibodies.
Monoclonal antibodies (mAbs), 4H2 and 6H7, were prepared previously using a protein conjugate of a 1:1 epimeric mixture of the synthetic ABC-ring fragments of ciguatoxin (CTX), 3 and 4. Here, theExpand
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Thermodynamic and structural basis for transition-state stabilization in antibody-catalyzed hydrolysis.
Catalytic antibodies 6D9 and 9C10, which were induced by immunization with a haptenic transition-state analog (TSA), catalyze the hydrolysis of a nonbioactive chloramphenicol monoester derivative toExpand
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Verbindungen mit SiSi‐, GeGe‐ und SnSn‐Doppelbindungen sowie gespannte Ringsysteme mit Si‐, Ge‐ und Sn‐Gerüsten
Als Hohepunkte auf dem Gebiet der Organoelementchemie der schwereren Elemente der vierten Hauptgruppe (Gruppe 14 des Periodensystems) in den 80er Jahren gelten die Darstellung und vollstandigeExpand
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Molecular design of small organic molecules based on structural information for a conformationally constrained peptide that binds to G-CSF receptor.
Based on structural information for a peptide (P8-2KAQ) that binds to granulocyte-colony stimulating factor receptor (G-CSFR), small ligands with a biaryl scaffold were designed and their bindingExpand
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Selection of inhibitory peptides for Aurora-A kinase from a phage-displayed library of helix-loop-helix peptides.
Conformationally constrained peptide libraries have been made by grafting randomized amino acid sequences onto a rigid scaffold derived from natural proteins. Here, as a library scaffold, we proposeExpand
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