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Rice plants take up iron as an Fe3+-phytosiderophore and as Fe2+.
TLDR
Analysis using the positron-emitting tracer imaging system showed that rice plants are able to take up both an Fe3+-phytosiderophore and Fe2+, indicating that rice possesses a novel Fe-uptake system that directly absorbs the Fe2+, a strategy that is advantageous for growth in submerged conditions. Expand
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
TLDR
The metabolic responses of a MYC-inducible human Burkitt lymphoma model P493 cell line to aerobic and hypoxic conditions, and to glucose deprivation, are determined using stable isotope-resolved metabolomics to demonstrate an alternative energy-generating glutaminolysis pathway involving a glucose-independent TCA cycle. Expand
Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES).
TLDR
BPTES is a unique and potent inhibitor of rat KGA and elucidates a novel mechanism of inactivation, which established that BPTES prevents the formation of large phosphate-induced oligomers and instead promotes theformation of a single oligomeric species with distinct physical properties. Expand
Rice metal-nicotianamine transporter, OsYSL2, is required for the long-distance transport of iron and manganese.
TLDR
Results indicate that the altered expression of OsYSL2 changes the localization of Fe, and that OsY SL2 is a critical Fe-nicotianamine transporter important for Fe translocation, especially in the shoots and endosperm. Expand
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.
TLDR
The results suggest that the metabolic profiles of tumors are likely to depend on both the genotype and tissue of origin and have implications regarding the design of therapies targeting tumor metabolism. Expand
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
TLDR
The ability to selectively slow growth in cells with IDH1 mutations by inhibiting glutaminase suggests a unique reprogramming of intermediary metabolism and a potential therapeutic strategy. Expand
Synthesis and biological evaluation of D-amino acid oxidase inhibitors.
TLDR
Oral administration of CBIO in conjunction with d-serine enhanced the plasma and brain levels of d-Serine in rats compared to the oral administration of d -serine alone. Expand
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer
TLDR
It is found that low‐invasive ovarian cancer (OVCA) cells are glutamine independent, whereas high-invasive OVCA cells are markedly glutamine dependent, and the ratio of gene expression associated with glutamine anabolism versus catabolism has emerged as a novel biomarker for patient prognosis. Expand
Co-Administration of a D-Amino Acid Oxidase Inhibitor Potentiates the Efficacy of D-Serine in Attenuating Prepulse Inhibition Deficits After Administration of Dizocilpine
TLDR
Findings suggest that coadministration of CBIO significantly enhanced the efficacy of D-serine in attenuating PPI deficits by administration of dizocilpine, and coadministation of D -serine and a DAAO inhibitor has therapeutic potential for the treatment of schizophrenia. Expand
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
TLDR
In an attempt to identify more potent GLS inhibitors with improved drug-like molecular properties, a series of BPTES analogs were synthesized and evaluated and revealed that some truncated analogs retained the potency of B PTES, presenting an opportunity to improve its aqueous solubility. Expand
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