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Expression in Escherichia coli of a New Multidrug Efflux Pump, MexXY, from Pseudomonas aeruginosa
Two new genes (mexXY) similar to mexAB,mexCD, and mexEF and mediating multidrug resistance were cloned from the chromosome of Pseudomonas aeruginosa and confers higher resistance to fluoroquinolones than the MexAB and MexCD systems.
NorM, a Putative Multidrug Efflux Protein, of Vibrio parahaemolyticus and Its Homolog in Escherichia coli
It is found that cells of Vibrio parahaemolyticus possess an energy-dependent efflux system for norfloxacin and NorM seems to be a novel type of multidrug efflux protein.
Functional Cloning and Characterization of a Plant Efflux Carrier for Multidrug and Heavy Metal Detoxification*
Functional analysis of At DTX1 protein in KAM3 mutant demonstrated that AtDTX1 serves as an efflux carrier for plant-derived alkaloids, antibiotics, and other toxic compounds and was also capable of detoxifying Cd2+, a heavy metal.
Multidrug efflux transporters in the MATE family.
Cloning and Sequencing of the Gene for Na+/H+Antiporter ofVibrio parahaemolyticus
A gene encoding an Na+/H+antiporter was cloned from Vibrio parahaemolyticus into the plasmid pBR322 and expressed in Escherichia colicells and deduced amino acid sequence was found to be 72% identical to the NhaB Na+.
A new Na+/H+ antiporter, NhaD, of Vibrio parahaemolyticus.
Cloning and sequencing of the gene for Na+/H+ antiporter of Vibrio parahaemolyticus.
A gene encoding an Na+/H+ antiporter was cloned from vibrio parahaemolyticus into the plasmid pBR322 and expressed in Escherichia coli cells. The gene enabled mutant E. coli cells to grow in the
A Putative Multisubunit Na+/H+ Antiporter fromStaphylococcus aureus
Hydropathy analysis of the deduced amino acid sequences of the seven ORFs suggested that all of the proteins are hydrophobic, and components of the respiratory chain showed sequence similarity with putative subunits of the Na+/H+ antiporter.
AbeM, an H+-Coupled Acinetobacter baumannii Multidrug Efflux Pump Belonging to the MATE Family of Transporters
A gene, abeM, for a multidrug efflux pump from Acinetobacter baumannii using Escherichia coli as the host and sequence analysis revealed that AbeM is a member of the MATE family of pumps.
Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE).
An extract from Salvia officinalis (Sage) leaves showed antimicrobial activity against vancomycin-resistant enterococci (VRE). We isolated the effective compound and identified it as oleanolic acid,