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Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring
TLDR
The data validate the amelioration observed with bumetanide and oxytocin and point to common pathways in a drug-induced and a genetic rodent model of autism.
GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction
TLDR
It is demonstrated that about 20% of cases of LKS, CSWSS and electroclinically atypical rolandic epilepsy often associated with speech impairment can have a genetic origin sustained by de novo or inherited mutations in the GRIN2A gene (encoding the N-methyl-D-aspartate (NMDA) glutamate receptor α2 subunit, GluN2A).
Early Gamma Oscillations Synchronize Developing Thalamus and Cortex
TLDR
It is proposed that the multiple replay of sensory input in thalamocortical circuits during EGOs allows thalamic and cortical neurons to be organized into vertical topographic functional units before the development of horizontal binding in adult brain.
Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape ‘superslow’ afterburst EPSC in rat hippocampus
TLDR
Long‐term potentiation (LTP) induced by successive rounds of burst stimulation is accompanied by a long‐term increase in the contribution of extrasynaptic receptors in the afterburst EPSCNMDA.
Glycine Receptors in CNS Neurons as a Target for Nonretrograde Action of Cannabinoids
TLDR
It is demonstrated that cannabinoids may directly affect the functioning of inhibitory glycine receptor (GlyR) channels and that the direct inhibition of GlyRs by endocannabinoids can modulate the hippocampal network activity.
N-Methyl-d-aspartate (NMDA) Receptor NR2 Subunit Selectivity of a Series of Novel Piperazine-2,3-dicarboxylate Derivatives: Preferential Blockade of Extrasynaptic NMDA Receptors in the Rat
TLDR
Consistent with a physiological role for NR2D-containing receptors in the hippocampus, UBP141 displayed greater selectivity than PPDA for inhibiting the slow-decaying component of the NMDA receptor-mediated CA3-CA1 synaptic response in rat hippocampal slices.
Distinct Actions of Voltage-Activated Ca2+ Channel Block on Spontaneous Release at Excitatory and Inhibitory Central Synapses
TLDR
It is reported that in mouse neocortical neurons, selective and nonselective VACC blockers inhibit spontaneous release at inhibitory but not at excitatory terminals, and that this pattern is observed in culture and slice preparations as well as in synapses from acute slices of the auditory brainstem.
Large, stable spikes exhibit differential broadening in excitatory and inhibitory neocortical boutons
TLDR
Large presynaptic spikes are reported from boutons of neocortical pyramidal neurons and interneurons and demonstrate fundamental differences between excitatory and inhibitory boutons in the neocortex.
Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model
TLDR
It is reported that tuberless heterozygote Tsc1+/− mice show functional upregulation of cortical GluN2C-containing N-methyl-D-aspartate receptors (NMDARs) in an mTOR-dependent manner and exhibit recurrent, unprovoked seizures during early postnatal life, which constitutes a promising molecular target to treat epilepsy in TSC patients.
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