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High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load.
Baseline levels of HBsAg and HBV were associated with development of HCC, and risk increased with level, while among patients infected with HBV genotype B or C, determinants of H CC risk include their sex, age, hepatitis B e antigen status, HBv genotype, and levels of alanine aminotransferase and HBv DNA, but not level ofHBsAg. Expand
Effect of host and viral factors on hepatitis B e antigen-positive chronic hepatitis B patients receiving pegylated interferon-α-2a therapy.
BCP mutation is associated with higher HBeAg seroconversion and combined response rates at 6 months off therapy in H beAg-positive chronic hepatitis B patients treated with PEG-IFN-α-2a. Expand
Serum hepatitis B surface antigen levels predict surface antigen loss in hepatitis B e antigen seroconverters.
Low serum levels of HBsAg, alone or in combination with HBV DNA levels, 1 year after HBeAg seroconversion can predictHBsAg loss in patients with HBv genotype B or C infection. Expand
Pegylated interferon-alpha-2a plus ribavirin for treatment-naive Asian patients with hepatitis C virus genotype 1 infection: a multicenter, randomized controlled trial.
- Chen-Hua Liu, Chun-Jen Liu, +11 authors J. Kao
- Clinical infectious diseases : an official…
- 15 November 2008
In treatment-naive Asian patients with HCV-1 infection, 48 weeks of pegylated IFN-alpha-2a plus ribavirin therapy is associated with a higher SVR rate, compared with 24 weeks of such therapy. Expand
Hepatitis B virus–specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation
- L. Rivino, N. Le Bert, +13 authors A. Bertoletti
- The Journal of clinical investigation
- 8 January 2018
This study identifies the presence of functional HBV-specific T cells as a candidate immunological biomarker for safe therapy discontinuation in chronic HBV patients and highlights the potential beneficial role of the expression of T cell exhaustion markers during human chronic viral infection. Expand
Male sex, hiatus hernia, and Helicobacter pylori infection associated with asymptomatic erosive esophagitis
- Pin-Chao Wang, Ching-Sheng Hsu, +5 authors Chia-Chi Wang
- Journal of gastroenterology and hepatology
- 1 March 2012
Background and Aims: Asymptomatic erosive esophagitis (AEE) is an easily forgotten subgroup of gastroesophageal reflux disease due to its lack of warning symptoms, despite having the risk of… Expand
Serum hepatitis B surface antigen levels help predict disease progression in patients with low hepatitis B virus loads
In HBeAg‐negative patients with low viral loads and genotype B or C virus infection, a higher HBsAg level can predict disease progression, and this should help define minimal‐risk HBV carriers. Expand
Serum microRNA-122 level correlates with virologic responses to pegylated interferon therapy in chronic hepatitis C
- T. Su, Chen-Hua Liu, +6 authors Ding-Shinn Chen
- Proceedings of the National Academy of Sciences
- 23 April 2013
High pretreatment serum miR-122 level can help predict virologic responses to pegylated IFN plus ribavirin therapy and may serve as a surrogate of hepatic mi R-122, according to patients with chronic hepatitis C. Expand
Increasing insulin resistance is associated with increased severity and prevalence of gastro‐oesophageal reflux disease
Aliment Pharmacol Ther 2011; 34: 994–1004
Clinical utility of quantitative HBsAg in natural history and nucleos(t)ide analogue treatment of chronic hepatitis B: new trick of old dog
Taking these lines of evidence together, qHBsAg can complement HBV-DNA levels to optimize the management of CHB patients in the authors' daily clinical practice. Expand