UPLC/ESI-MS/MS-based determination of metabolism of several new illicit drugs, ADB-FUBINACA, AB-FUBINACA, AB-PINACA, QUPIC, 5F-QUPIC and α-PVT, by human liver microsome.
- Takahiro Takayama, Mayu Suzuki, T. Toyo’oka
- Chemistry, BiologyBiomedical chromatography : BMC
- 1 June 2014
The proposed approach using human liver microsome seems to provide a new technology for the prediction of possible metabolites occuring in humans for drugs investigated using reversed-phase chromatography and mass spectrometry.
Recent advances in separation and detection methods for thiol compounds in biological samples.
- T. Toyo’oka
- Chemistry, BiologyJournal of chromatography. B, Analytical…
- 15 October 2009
Simultaneous determination of D- and L-serine in rat brain microdialysis sample using a column-switching HPLC with fluorimetric detection.
- T. Fukushima, Junko Kawai, K. Imai, T. Toyo’oka
- Biology, ChemistryBiomedical chromatography : BMC
- 1 December 2004
The proposed HPLC method will be useful for in vivo studies on D-serine, which acts as a coagonist for N-methyl-D-aspartate receptor, to the extracellular fluid of rat brain.
High-performance liquid chromatography and fluorometric detection of biologically important thiols, derivatized with ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate (SBD-F).
Further studies on the reaction of amines and proteins with 4-fluoro-7-nitrobenzo-2-oxa-1,3-diazole
A specific LC/ESI-MS/MS method for determination of 25-hydroxyvitamin D3 in neonatal dried blood spots containing a potential interfering metabolite, 3-epi-25-hydroxyvitamin D3.
The developed method enabled specific quantification of 25(OH)D(3) in neonatal DBSs and detection of vitamin D deficiency without interference from 3-epi-25-hydroxyvitamin D(3).
Investigation of chromatographic performances and binding characteristics of BSA-encapsulated capillary column prepared by the sol-gel method.
Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry.
Improved method for the determination of kynurenic acid in rat plasma by column-switching HPLC with post-column fluorescence detection