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Allodynia and Hyperalgesia in Adjuvant-Induced Arthritic Rats: Time Course of Progression and Efficacy of Analgesics
The present study provided integrated information about the time course of pain and other disease development parameters in the CFA-induced arthritic rats, and clarified acute efficacies of different categories of analgesics for the allodynia and hyperalgesia.
Radioligand Binding Properties and Pharmacological Characterization of 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a High-Affinity, Selective, and…
- A. Kohara, T. Toya, M. Okada
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 October 2005
YM-298198 is a newly synthesized, high-affinity, selective, and noncompetitive antagonist of mGluR1 that will be a useful pharmacological tool due to its highly active properties in vitro and in vivo.
Cloning and expression of a cDNA for the rat kappa-opioid receptor.
Northern blot analysis demonstrated that kappa-opioid receptor mRNA is expressed in a regionally specific manner in rat brain.
Cloning and expression of a cDNA for the rat k‐opioid receptor
Mechanisms of somatic embryogenesis in cell cultures : physiology, biochemistry, and molecular biology
The mechanism of somatic embryogenesis is one of the most fundamental problems in plant physiology and has attracted attention in plant biotechnology, because it can provide useful systems to produce transgenic clone plants as well as to obtain materials of artificial seeds.
Neurometer measurement of current stimulus threshold in rats.
- T. Kiso, Y. Nagakura, T. Yamaguchi
- Biology, PsychologyThe Journal of pharmacology and experimental…
- 1 April 2001
The results suggest that the Neurometer makes possible selective examination of subsets of nerve fibers that differ in diameter not only in humans but also in animals, and may provide helpful suggestions for the interpretation of data in humans.
Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models.
In situ hybridization study of κ-opioid receptor mRNA in the rat brain
YM872, a novel selective alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, reduces brain damage after permanent focal cerebral ischemia in cats.
- M. Takahashi, J. Ni, T. Yamaguchi
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 February 1998
Evidence for the neuroprotective efficacy of YM872 suggests its therapeutic potential in the treatment of acute stroke in humans and supports the notion that the AMPA receptor plays an important role in the progression of focal ischemic damage in a gyrencephalic model.
Isolation of a carrot gene expressed specifically during early-stage somatic embryogenesis
- Shigeru Sato, T. Toya, R. Kawahara, R. Whittier, H. Fukuda, A. Komamine
- BiologyPlant Molecular Biology
- 1 April 1995
The amino acid sequence deduced from the nucleotide sequence of the CEM6 cDNA indicates that it encodes a glycine-rich protein containing a hydrophobic signal-sequence like domain, which suggest an important role as a cell wall protein in embryogenesis.