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Solitary pancreatic metastasis occurring eight years after nephrectomy for renal cell carcinoma
- T. Hirota, T. Tomida, M. Iwasa, Kazuei Takahashi, M. Kaneda, H. Tamaki
- International journal of pancreatology : official…
- 30 March 1996
SummaryConclusionPancreatic metastasis from renal cell carcinoma is extremely rare. The average time between nephrectomy and the diagnosis of metachronous metastases is reported to exceed 10 yr.… Expand
Inhibition of COX-2 prevents hypertension and proteinuria associated with a decrease of 8-iso-PGF2α formation in l-NAME-treated rats
Background The inhibition of nitric oxide (NO) exerts injurious effects on the cardiovascular system by several mechanisms, such as the activation of the renin–angiotensin system, oxidative stress,… Expand
Decrease in Renal Medullary Endothelial Nitric Oxide Synthase of Fructose-Fed, Salt-Sensitive Hypertensive Rats
We investigated the expression of endothelial NO synthase (eNOS) in the kidneys of fructose-fed insulin-resistant rats (FFR) with a low- or high-sodium diet. Male Sprague-Dawley rats were fed a… Expand
Effect of quinapril on intimal hyperplasia after coronary stenting as assessed by intravascular ultrasound.
We studied whether angiotensin-converting enzyme inhibition with quinapril treatment can prevent in-stent restenosis after successful implantation of Palmaz-Schatz stents. Intravascular ultrasound… Expand
Quinapril Treatment Restores The Vasodilator Action Of Insulin In Fructose‐Hypertensive Rats
- T. Uchida, K. Okumura, +6 authors T. Hayakawa
- Medicine, Chemistry
- Clinical and experimental pharmacology…
- 1 May 2002
1. Angiotensin‐converting enzyme (ACE) inhibitors have been shown to improve insulin‐resistance both experimentally and clinically. We therefore investigated the effects of quinapril, which has high… Expand
Relation of a Common Methylenetetrahydrofolate Reductase Mutation and Plasma Homocysteine With Intimal Hyperplasia After Coronary Stenting
BackgroundHyperhomocysteinemia has been identified as an independent risk factor for coronary artery disease. Recent studies have shown that a common mutation (nucleotide 677 C→T) in the… Expand
The Glu298Asp polymorphism in endothelial nitric oxide synthase gene is associated with coronary in-stent restenosis.
- T. Suzuki, K. Okumura, +9 authors T. Hayakawa
- International journal of cardiology
- 1 November 2002
BACKGROUND Reduced or impaired synthesis of nitric oxide promotes the proliferation of vascular smooth muscle cells, and thus may induce the neointimal formation leading to coronary in-stent… Expand
Altered expression of prostacyclin synthase in a subset of the thick ascending limb cells and mesangial cells in 5/6-nephrectomized rats.
- T. Tomida, Y. Numaguchi, +4 authors T. Hayakawa
- Hypertension research : official journal of the…
- 1 July 2001
The aim of this study was to evaluate the possible role of prostacyclin (PGl2) in the onset and development of hypertension and chronic renal failure in 5/6-nephrectomized rats (5/6NX). We measured… Expand
Alcohol ingestion enhances hepatocarcinogenesis induced by synthetic estrogen and progestin in the rat.
We examined the effect of alcohol ingestion on rat hepatocarcinogenesis induced by oral administration of synthetic female hormones, 0.075 mg of ethynylestradiol (EE) and 6.0 mg of norethindrone… Expand
Calcineurin inhibitor attenuates cardiac hypertrophy due to energy metabolic disorder.
- H. Kamiya, K. Okumura, +5 authors T. Hayakawa
- The Canadian journal of cardiology
- 1 December 2001
BACKGROUND Several studies have shown that calcineurin may play a critical role in the signalling of cardiac hypertrophy in various experimental models. OBJECTIVE To elucidate whether calcineurin… Expand