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Extracellular DNA required for bacterial biofilm formation.
TLDR
Bacterial biofilms are structured communities of cells enclosed in self-produced hydrated polymeric matrix adherent to an inert or living surface that have inherent resistance to antibiotics and host immune attack.
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A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms
TLDR
Experiments with P. aeruginosa strains indicated that the extracellular DNA is generated via a mechanism which is dependent on acyl homoserine lactone and Pseudomonas quinolone signalling, as well as on flagella and type IV pili.
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Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants
TLDR
Dynamics and selection during biofilm formation were investigated by tagging the wild type and flagella/type IV mutants with Yfp and Cfp and performing time‐lapse confocal laser scanning microscopy in mixed colour biofilms, which revealed dynamic compositions with extensive motility, competition and selection occurring during development.
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Burkholderia Type VI Secretion Systems Have Distinct Roles in Eukaryotic and Bacterial Cell Interactions
TLDR
The data show that T6SSs within a single organism can have distinct functions in eukaryotic versus bacterial cell interactions, and are likely to be a decisive factor in the survival of bacterial cells of one species in intimate association with those of another, such as in polymicrobial communities present both in the environment and in many infections.
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Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis.
TLDR
Evidence is presented that extracellular DNA is important for the initial phase of biofilm development by S. epidermidis on polystyrene or glass surfaces under static or hydrodynamic conditions, and that the ext racellular DNA promotes biofilm formation of the remaining population.
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Cell Death in Pseudomonas aeruginosa Biofilm Development
TLDR
It is proposed that prophage-mediated cell death is an important mechanism of differentiation inside microcolonies that facilitates dispersal of a subpopulation of surviving cells in biofilms of P. aeruginosa.
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Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms
TLDR
It is shown that mushroom‐shaped multicellular structures in P. aeruginosa biofilms can form in a sequential process involving a non‐motile bacterial subpopulation and a migrating bacterial sub population.
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Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa.
TLDR
Evidence is provided that DNA release in P. aeruginosa PAO1 biofilms is also under iron regulation, and that expression of the pqs operon was induced in particular subpopulations of the biofilm cells under low-iron conditions, but repressed in the bio film cells under high- iron conditions.
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Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms.
TLDR
Evidence is presented that type IV pili, flagellum-mediated motility and quorum sensing-controlled DNA release are involved in the formation of mature multicellular structures in P. aeruginosa biofilms.
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Fluorescence-Based Reporter for Gauging Cyclic Di-GMP Levels in Pseudomonas aeruginosa
TLDR
Fluorescent monitors that can gauge the cellular level of cyclic di-GMP in P. aeruginosa and display a significant potential for use in the identification of novel antipathogenic compounds targeting cyclicDiGMP signaling are described.
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