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Extracellular DNA required for bacterial biofilm formation.
Bacterial biofilms are structured communities of cells enclosed in self-produced hydrated polymeric matrix adherent to an inert or living surface ([1][1]). Formation of these sessile communities andExpand
A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms
Pseudomonas aeruginosa produces extracellular DNA which functions as a cell‐to‐cell interconnecting matrix component in biofilms. Comparison of extracellular DNA and chromosomal DNA by the use ofExpand
Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants
Biofilm formation by Gfp‐tagged Pseudomonas aeruginosa PAO1 wild type, flagella and type IV pili mutants in flow chambers irrigated with citrate minimal medium was characterized by the use ofExpand
Burkholderia Type VI Secretion Systems Have Distinct Roles in Eukaryotic and Bacterial Cell Interactions
Bacteria that live in the environment have evolved pathways specialized to defend against eukaryotic organisms or other bacteria. In this manuscript, we systematically examined the role of the fiveExpand
Cell death in Pseudomonas aeruginosa biofilm development.
Bacteria growing in biofilms often develop multicellular, three-dimensional structures known as microcolonies. Complex differentiation within biofilms of Pseudomonas aeruginosa occurs, leading to theExpand
Role of autolysin-mediated DNA release in biofilm formation of Staphylococcus epidermidis.
Staphylococcus epidermidis has become a serious nosocomial pathogen frequently causing infections associated with implanted foreign materials. Biofilm formation is considered a major factorExpand
Involvement of bacterial migration in the development of complex multicellular structures in Pseudomonas aeruginosa biofilms
Detailed knowledge of the developmental process from single cells scattered on a surface to complex multicellular biofilm structures is essential in order to create strategies to control biofilmExpand
Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa.
Extracellular DNA is one of the major matrix components in Pseudomonas aeruginosa biofilms. It functions as an intercellular connector and plays a role in stabilization of the biofilms. Evidence thatExpand
Roles of type IV pili, flagellum-mediated motility and extracellular DNA in the formation of mature multicellular structures in Pseudomonas aeruginosa biofilms.
When grown as a biofilm in laboratory flow chambers Pseudomonas aeruginosa can develop mushroom-shaped multicellular structures consisting of distinct subpopulations in the cap and stalk portions. WeExpand
Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB‐oprM genes
Bacteria living as biofilm are frequently reported to exhibit inherent tolerance to antimicrobial compounds, and might therefore contribute to the persistence of infections. Antimicrobial peptidesExpand
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