T. Tokunaga

Publications176
h-index33
Citations5,412
Highly Influential Citations120
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Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study
TLDR
This study wanted to set objective clinical criteria for the diagnosis of refractory CRS, and found that CRSwNP displays more intense eosinophilic infiltration and the presence of Th2 cytokines.
DNA from Bacteria, but Not from Vertebrates, Induces Interferons, Activates Natural Killer Cells and Inhibits Tumor Growth
TLDR
The nucleic acid fraction from cells of 6 species of bacterium and 2 kinds of vertebrate, calf and salmon, was extracted and purified and it was shown that the factor to activate macrophages was interferon (IFN)‐gamma and that to inhibit viral growth was IFN‐alpha/beta.
Synthetic Oligonucleotides with Particular Base Sequences from the cDNA Encoding Proteins of Mycobacterium bovis BCG Induce Interferons and Activate Natural Killer Cells
TLDR
It is suggested that certain palindrome sequences, like GACGTC, GGCGCC and TGCGCA, are essential for 30‐mer oligonucleotides, like BCG‐A4a, to induce IFNs.
Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity.
TLDR
A fraction extracted from Mycobacterium bovis strain BCG, which was composed of 70% DNA, 28.0% RNA, 1.3% protein, 0.20% glucose, and 0.1% lipid, was found to possess strong antitumor activity, suggesting that the DNA from BCG possessed strong antitUMor activity under certain conditions.
Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.
TLDR
The results strongly suggest that the presence of the unique palindromic sequences, such as GACGTC, AGCGCT, and AACGTT, but not ACCGGT, is essential for the immunostimulatory activity of oligonucleotides.
Human soluble IL-6 receptor: its detection and enhanced release by HIV infection.
TLDR
The results suggest that the release of soluble IL-6R might be linked to regulatory functions of immune responses induced by IL- 6 stimulation during normal and human retrovirus-infected cell growth and differentiation.
Synthetic Oligonucleotides with Certain Palindromes Stimulate Interferon Production of Human Peripheral Blood Lymphocytes in vitro
TLDR
When PBL was cultured with oligoDNA having a palindrome of AACGTT or GACGTC, IFN activity was detected by bioassay in the culture fluid after 8 h, and the amount of IFN reached the maximum after 18 h.
In vivo effect of anti-asialo GM1 antibody on natural killer activity
TLDR
Intraperitoneal injection of microlitre amounts of anti-asialo GM1 into BALB/c nu/nu mice almost completely abolishes NK activity and enhances the local growth of syngeneic lymphoma, RL♂1 as well as the incidence of tumour take.
In vitro Augmentation of Natural Killer Cell Activity and Production of Interferon‐α/β and ‐γ with Deoxyribonucleic Acid Fraction from Mycobacterium bovis BCG
A nucleic acid‐rich fraction extracted and purified from BCG (MY‐1) augmented natural killer (NK) cell activity of mouse spleen cells in vitro, and produced factor(s) which showed anti‐viral activity…
Baicalin, an inhibitor of HIV-1 production in vitro.
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