UV absorption method should not be applied for determining amoxycillin in acidic dissolution test medium.
- T. Tokumura, Y. Machida
- Chemistry, EngineeringInternational journal of pharmaceutics
- 9 October 2001
Enhancement of the oral bioavailability of cinnarizine in oleic acid in beagle dogs.
- T. Tokumura, Y. Tsushima, K. Tatsuishi, M. Kayano, Y. Machida, T. Nagai
- Chemistry, BiologyJournal of Pharmacy and Science
- 1 April 1987
The present study was an attempt to develop a new dosage form of cinnarizine, which is slightly soluble in water, using lipid as a vehicle, and it was found that cinnARizine dissolved well in oleic and linoleic acids.
Pharmacokinetics of novel hexapeptides with neurotensin activity in rats.
- R. Machida, T. Tokumura, Y. Tsuchiya, A. Sasaki, K. Abe
- Chemistry, BiologyBiological and Pharmaceutical Bulletin
- 15 January 1993
It was found that NT-1 was more suitable for oral administration than NT-2, and the pharmacokinetic profiles of NT- 2 after intravenous administration ofNT-1 at doses of 0.1 and 0.3 mg/kg were compatible with that of NT (Me)Arg-Lys-Pro-Trp-tert-leu-Leu- Leu-OEt.
Evaluation of the bioavailability of flurbiprofen and its beta-cyclodextrin inclusion complex in four different doses upon oral administration to rats.
- Atsushi Muraoka, T. Tokumura, Y. Machida
- Chemistry, MedicineEuropean journal of pharmaceutics and…
- 1 November 2004
Inclusion complexes of cinnarizine with beta-cyclodextrin in aqueous solution and in the solid state.
- T. Tokumura, H. Ueda, T. Nagai
- ChemistryChemical and pharmaceutical bulletin
- 25 October 1984
Inclusion complex formation of cinnarizine with β-cyclodextrin in aqueous solution and in the solid state was confirmed by the solubility method, powder X-ray diffractometry, differential scanning…
Enhancement of bioavailability of cinnarizine from its beta-cyclodextrin complex on oral administration with DL-phenylalanine as a competing agent.
- T. Tokumura, Y. Tsushima, M. Kayano, Y. Machida, T. Nagai
- ChemistryJournal of Pharmacy and Science
- 1985
Inclusion complex of cinnarizine withβ-cyclodextrin in aqueous solution and in solid state
- T. Tokumura, H. Ueda, T. Nagai
- Chemistry
- 1 September 1984
Inclusion complex formation of cinnarizine (CN) with β-cyclodextrin (β-CD) in aqueous solution and in solid state was confirmed by the solubility method, powder X-ray diffractometry, differential…
Determination of metronidazole in a rat stomach by HPLC for obtaining basic data of the eradication therapy of Helicobacter pylori
- Mai Kubodera, T. Tokumura, Y. Machida
- MedicineJournal of Pharmaceutical Analysis
- 14 March 2012
Preparation of amoxicillin intragastric buoyant sustained-release tablets and the dissolution characteristics.
- T. Tokumura, Y. Machida
- Chemistry, BiologyJournal of Controlled Release
- 21 February 2006
Kinetics of nikkomycin Z degradation in aqueous solution and in plasma.
- T. Tokumura, T. Horie
- Biology, ChemistryBiological and Pharmaceutical Bulletin
- 15 May 1997
The stability of nikkomycin Z in aqueous solution at various pH values and in the plasma of several kinds of experimental animals was studied and the degradation rate in rat, mouse, rabbit, and rabbit plasma was markedly decreased when NaF, an esterase inhibitor, was added to the plasma.
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