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Guidelines for management of idiopathic normal pressure hydrocephalus: second edition.
Among the various disorders manifesting dementia, gait disturbance, and urinary incontinence in the elderly population, idiopathic normal pressure hydrocephalus (iNPH) is becoming of great… Expand
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease
Background: To date, there is no accepted clinical diagnostic test for Parkinson disease (PD) that is based on biochemical analysis of blood or CSF. The discovery of mutations in the SNCA gene… Expand
High‐molecular‐weight β‐amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients
- H. Fukumoto, T. Tokuda, +5 authors M. Nakagawa
- Chemistry, Medicine
- FASEB journal : official publication of the…
- 1 August 2010
There is accumulating evidence that soluble amyloid‐β (Aβ) oligomers, rather than amyloid fibrils, are the principal pathogenic species in Alzheimer disease (AD). Here, we have developed a novel… Expand
Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease.
There is ample biochemical, pathological, and genetic evidence that the metabolism of alpha-synuclein (alpha-syn) plays a crucial role in the pathogenesis of Parkinson disease (PD). To examine… Expand
Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease.
There is ample biochemical, pathological, and genetic evidence that the metabolism of -synuclein (-syn) plays a crucial role in the pathogenesis of Parkinson disease (PD). To examine whether… Expand
Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid β-protein and tau protein
SummaryA histopathological study was carried out on the brains of eight ex-boxers (ages 56 to 83) using conventional histological staining methods and immunocytochemistry with antibodies to amyloid… Expand
p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions
α-Synuclein is the main component of Lewy bodies, the intraneuronal inclusion bodies characteristic of Parkinson’s disease. Although α-synuclein accumulation is caused by inhibition of proteasome and… Expand
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of &agr;-Synuclein Misfolded Aggregates in Cerebrospinal Fluid
Importance Parkinson disease (PD) is a highly prevalent and incurable neurodegenerative disease associated with the accumulation of misfolded &agr;-synuclein (&agr;Syn) aggregates. An important… Expand
Differential levels of α-synuclein, β-amyloid42 and tau in CSF between patients with dementia with Lewy bodies and Alzheimer's disease
- K. Kasuga, Takayoshi Tokutake, +5 authors T. Ikeuchi
- Journal of Neurology, Neurosurgery & Psychiatry
- 1 June 2010
Background The clinical diagnosis of dementia with Lewy bodies (DLB) is made on the basis of consensus criteria; however, the sensitivity of the criteria is relatively low. There are no generally… Expand
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
BackgroundDespite decades of intensive research, to date, there is no accepted diagnosis for Parkinson’s disease (PD) based on biochemical analysis of blood or CSF. However, neurodegeneration in the… Expand