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Cardioprotective Effects of Short-Term Caloric Restriction Are Mediated by Adiponectin via Activation of AMP-Activated Protein Kinase
Background— Overeating and obesity are major health problems in developed countries. Caloric restriction (CR) can counteract the deleterious aspects of obesity-related diseases and prolong lifespan.… Expand
The regulatory T cell gene FOXP3 and genetic susceptibility to thyroid autoimmunity: an association analysis in Caucasian and Japanese cohorts.
FOXP3 is a key gene in the development of regulatory T cells (Treg). FOXP3 expression commits naïve T cells to become Treg cells. Indeed, mutations in the FOXP3 gene cause severe systemic autoimmune… Expand
Comparison of Serum High–Molecular Weight (HMW) Adiponectin With Total Adiponectin Concentrations in Type 2 Diabetic Patients With Coronary Artery Disease Using a Novel Enzyme-Linked Immunosorbent…
Adiponectin (Acrp30), an adipocyte-derived protein, exists in serum as a trimer, a hexamer, and a high–molecular weight (HMW) form, including 12–18 subunits. Because HMW adiponectin may be… Expand
Inhibition by adiponectin of IL-8 production by human macrophages upon coculturing with late apoptotic cells.
- S. Saijo, K. Nagata, Y. Nakano, T. Tobe, Y. Kobayashi
- Medicine, Biology
- Biochemical and biophysical research…
- 9 September 2005
Adiponectin, an adipocyte-derived hormone, reportedly suppresses the production of TNF-alpha and IL-6 by LPS-stimulated human or porcine macrophages, and the phagocytosis of microbeads by human… Expand
A novel enzyme-linked immunosorbent assay specific for high-molecular-weight adiponectin Published, JLR Papers in Press, April 7, 2006.
- Yasuko Nakano, Sachiko Tajima, +6 authors T. Tobe
- Medicine, Chemistry
- Journal of Lipid Research
- 1 July 2006
Human plasma contains at least three forms of adiponectin: a trimer, a hexamer, and a high-molecular-weight (HMW) multimer. We purified HMW adiponectin from human plasma using its affinity to gelatin… Expand
Circulating Foxp3+CD4+ cell numbers in atopic patients and healthy control subjects.
Characterization of mouse GBP28 and its induction by exposure to cold
- M. Yoda, Y. Nakano, T. Tobe, S. Shioda, N-H Choi-Miura, M. Tomita
- International Journal of Obesity
OBJECTIVE: To investigate whether the expression of the novel adipose tissue-specific protein GBP28 in adipose tissue and serum are altered in mice under a variety of conditions.DESIGN: Mice were fed… Expand
Unique Membrane Interaction Mode of Group IIF Phospholipase A2*
- G. T. Wijewickrama, Alexandra Albanese, +10 authors W. Cho
- Biology, Medicine
- Journal of Biological Chemistry
- 27 October 2006
The mechanisms by which secretory phospholipases A2 (PLA2s) exert cellular effects are not fully understood. Group IIF PLA2 (gIIFPLA2) is a structurally unique secretory PLA2 with a long C-terminal… Expand
Improved resolution of the comparative horse-human map: investigating markers with in silico and linkage mapping approaches.
Genetic maps are extremely important tools for tracing the genes that govern economically significant traits, and microsatellites are a significant component of these. In this study, we isolated 2346… Expand
High-Molecular-Weight Adiponectin and Leptin Levels in Cord Blood Are Associated with Anthropometric Measurements at Birth
- M. Inoue, K. Itabashi, Y. Nakano, Yasuko Nakano, T. Tobe
- Hormone Research in Paediatrics
- 30 September 2008
Aims: High-molecular-weight adiponectin (HMW-ad) is an active form of adiponectin. No information is available with respect to HMW-ad in neonates. The aims of this study were to examine whether… Expand