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Ranitidine: single dose pharmacokinetics and absolute bioavailability in man.
The results suggest a more extensive biotransformation of ranitidine and biliary excretion of metabolites after oral administration while i.v. administration is suggested, as well as that runitidine is preferentially excreted unchanged in the urine.
Piperacillin: Human Pharmacokinetics After Intravenous and Intramuscular Administration
Probenecid (1 g given orally before administration of piperacillin) increased peak serum concentration, terminal serum half-life, and the area under the plasma concentration curve by 60%, and it decreased the apparent distribution volume and the renal clearance of the intramuscularly administered antibiotic by 40%.
Biotransformation of diflunisal and renal excretion of its glucuronides in renal insufficiency.
The present study indicates that although diflunisal is primarily eliminated by biotransformation, T½β is prolonged in renal insufficiency and dose adjustment will accordingly be required in patients with renal function impairment.
High‐Performance Liquid Chromatographic Determination of 12 Antiarrhythmic Drugs in Plasma Using Solid‐Phase Column Extraction
Monitoring of plasma concentrations of antiarrhythmic drugs may assist in individualizing dosage regimens and in assessing patient compliance with good recovery and linearity in the expected therapeutic ranges.
Comparative pharmacokinetics of ceftazidime and moxalactam
The pharmacokinetics of ceftazidime and moxalactam were compared after intravenous and intramuscular administration of single 1-g doses to eight healthy volunteers in a crossover study. The
Comparative multiple dose kinetics of two formulations of indomethacin
The results show that the bioavailability of the CR and conventional indomethacin formulations under these multiple-dose conditions was not significantly different.
Relative bioavailability of enteric coated pellets, stearate and ethylsuccinate formulations of erythromycin.
The extent of gastrointestinal absorption and bioavailability of erythromycin is apparently greater for the base pellets than for the stearate and ethylsuccinate formulations.
The effect of end-stage renal failure and haemodialysis on the elimination kinetics of sotalol.
Comparison of sotalol concentrations in plasma versus ultrafiltrate from the coil kidney indicates that the drug in vivo is negligible bound to plasma proteins in remal patients, and post-dialysis plasma concentration data suggest that the rate at which sotalols returns to plasma from body tissues appears to be the rate-controlling factor in the elimination of sotol by haemodialysis.
Biotransformation and excretion of lorazepam in patients with chronic renal failure.
Urinary excretion of lorazepam-glucuronide was found to be considerably decreased in chronic renal failure associated with accumulation of high concentrations of this conjugate in plasma during days after a single oral dose.
Effects of theophylline on canine diaphragmatic contractility and fatigue.
It is concluded that diaphragmatic tissue concentrations correlate well with therapeutic serum and supratherapeutic bath levels and that only high theophylline concentrations increase canine diaphagmatic contractility in vitro, and that none of the theophyLLine concentrations studied could protect diaphragem bundles against the development of low- or high-frequency fatigue in vitro.