T. Timonen

Publications129
h-index37
Citations6,365
Highly Influential Citations100
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Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL; MIM 221770), also known as Nasu-Hakola disease, is a recessively inherited disease characterized by a combination… Expand
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Characteristics of human large granular lymphocytes and relationship to natural killer and K cells
Recent evidence, has demonstrated an association between a subpopulation of peripheral blood mononuclear cells, morphologically identified as large granular lymphocytes (LGL), and natural killer (NK)… Expand
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ICAM-2 redistributed by ezrin as a target for killer cells
VERY little is known about the receptors and target molecules involved in natural killer (NK) cell activity. Here we present a model system in which interleukin-2-activated killing by NK cells… Expand
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Cancer incidence among 78,000 asthmatic patients.
The risk of cancer was evaluated among 77,952 asthma patients with bronchial asthma. The series was obtained through linkage of two registers: the Finnish Social Insurance Institution's file of… Expand
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IFN-alpha and IL-18 synergistically enhance IFN-gamma production in human NK cells: differential regulation of Stat4 activation and IFN-gamma gene expression by IFN-alpha and IL-12.
IFN-gamma, a product of NK and T cells, is a key cytokine contributing innate and adaptive immunity. IFN-gamma production is induced via direct cell-cell contacts with APC and IFN-gamma -producing… Expand
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Isolation of human NK cells by density gradient centrifugation.
Sedimentation characteristics of human NK cells in discontinuous Percoll density gradients were studied. NK activity against the leukaemic cell line K-562 peaked in a single low density fraction… Expand
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The ezrin protein family: membrane-cytoskeleton interactions and disease associations.
Ezrin, radixin, moesin and merlin form a subfamily of conserved proteins in the band 4.1 superfamily. Ezrin protein subfamily members act as linkers between the plasma membrane and the cytoskeleton.… Expand
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Natural killer cells: Endothelial interactions, migration, and target cell recognition
  • T. Timonen
  • Biology, Medicine
  • Journal of leukocyte biology
  • 1 December 1997
Natural killer (NK) cells form a unique third group of lymphocytes that differs from T and B cells in surface phenotype, target recognition, and function. By producing cytokines and exerting… Expand
  • 72
  • 3
Expression of integrins and other adhesion molecules on NK cells; Impact of IL‐2 on short‐ and long‐term cultures
We have investigated, using flow cytometry, the expression of 19 adhesion molecules on fresh and IL‐2‐activated NK cells. The study included β1, β2 and β3 integrins, CD2, CD54 and CD58 (belonging to… Expand
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Inhibition of human natural killer cell activity by cereulide, an emetic toxin from Bacillus cereus
The lipophilic toxin, cereulide, emitted by emetic food poisoning causing strains of Bacillus cereus, is a powerful mitochondria toxin. It is highly lipophilic and rapidly absorbed from the gut into… Expand
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