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Coordinated Control of Endothelial Nitric-oxide Synthase Phosphorylation by Protein Kinase C and the cAMP-dependent Protein Kinase*
Results show that regulation of eNOS activity involves coordinated signaling through Ser-1177 and Thr-495 by multiple protein kinases and phosphatases.
Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases.
- A. Flint, T. Tiganis, D. Barford, N. Tonks
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 4 March 1997
The results suggest that the EGF receptor is a bona fide substrate for PTP 1B in vivo and that one important function of PTP1B is to prevent the inappropriate, ligand-independent, activation of newly synthesized EGF receptors in the endoplasmic reticulum.
Reactive oxygen species enhance insulin sensitivity.
Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
- C. Fedele, L. Ooms, C. Mitchell
- Biology, MedicineProceedings of the National Academy of Sciences
- 2 December 2010
Evidence is provided that INPP4B functions as a tumor suppressor by negatively regulating normal and malignant mammary epithelial cell proliferation through regulation of the PI3K/Akt signaling pathway, and that loss of IN PP4B protein is a marker of aggressive basal-like breast carcinomas.
Epidermal Growth Factor Receptor and the Adaptor Protein p52Shc Are Specific Substrates of T-Cell Protein Tyrosine Phosphatase
Results indicate that TC45 recognizes not only selected substrates in a cellular context but also specific sites within substrates and thus may regulate discrete signaling events.
The Akt kinase signals directly to endothelial nitric oxide synthase
Reactive oxygen species and insulin resistance: the good, the bad and the ugly.
- T. Tiganis
- BiologyTIPS - Trends in Pharmacological Sciences
- 1 February 2011
Protein tyrosine phosphatase function: the substrate perspective.
The focus of this review will be on the current state of knowledge of PTP substrates and the approaches used to identify them, and proposed experimental criteria that should be satisfied in order to rigorously assign P TP substrates as bona fide.
Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat