T. Tiensuu

Publications14
h-index9
Citations1,479
Highly Influential Citations136
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The Listeria transcriptional landscape from saprophytism to virulence
The bacterium Listeria monocytogenes is ubiquitous in the environment and can lead to severe food-borne infections. It has recently emerged as a multifaceted model in pathogenesis. However, how this… Expand
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A trans-Acting Riboswitch Controls Expression of the Virulence Regulator PrfA in Listeria monocytogenes
Riboswitches are RNA elements acting in cis, controlling expression of their downstream genes through a metabolite-induced alteration of their secondary structure. Here, we demonstrate that two… Expand
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RNAs: regulators of bacterial virulence
RNA-based pathways that regulate protein expression are much more widespread than previously thought. Regulatory RNAs, including 5′ and 3′ untranslated regions next to the coding sequence, cis-acting… Expand
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A riboswitch-regulated antisense RNA in Listeria monocytogenes
Riboswitches are ligand-binding elements located in 5′ untranslated regions of messenger RNAs, which regulate expression of downstream genes. In Listeria monocytogenes, a vitamin B12-binding (B12)… Expand
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Cycles of light and dark co-ordinate reversible colony differentiation in Listeria monocytogenes
Recently, several light receptors have been identified in non‐phototrophic bacteria, but their physiological roles still remain rather elusive. Here we show that colonies of the saprophytic bacterium… Expand
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Caenorhabditis elegans lin-25: a study of its role in multiple cell fate specification events involving Ras and the identification and characterization of evolutionarily conserved domains.
Caenorhabditis elegans lin-25 functions downstream of let-60 ras in the genetic pathway for the induction of the 1 degrees cell fate during vulval development and encodes a novel 130-kD protein. The… Expand
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Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates.
Induction of vulval fates in the C. elegans hermaphrodite is mediated by a signal transduction pathway involving Ras and MAP kinase. Previous genetic analysis has suggested that two potential targets… Expand
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Blue-Light Inhibition of Listeria monocytogenes Growth Is Mediated by Reactive Oxygen Species and Is Influenced by σB and the Blue-Light Sensor Lmo0799
ABSTRACT Listeria monocytogenes senses blue light via the flavin mononucleotide-containing sensory protein Lmo0799, leading to activation of the general stress response sigma factor SigB (σB). In… Expand
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lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans.
lin-1 encodes an ETS domain transcription factor that functions downstream of a Ras/MAP kinase pathway mediating induction of the 1 degrees cell fate during vulval development in the C. elegans… Expand
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Flick of a switch: regulatory mechanisms allowing Listeria monocytogenes to transition from a saprophyte to a killer.
In contrast to obligate intracellular pathogens that can remain in relatively stable host-associated environments, the soil-living bacterial pathogen Listeria monocytogenes has to sense and respond… Expand
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