Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes
- D. Sugden, J. Vanecek, D. Klein, T. Thomas, W. Anderson
- BiologyNature
- 1985
The results suggest that kinase activation is involved and the data provide the first demonstration of a synergistic interaction between Ca2+-phospholipid-dependent protein kinase (protein kinase C) and neurotransmitter-dependent stimulation of cyclic AMP.
Hydrogen peroxide changes in ischemic and reperfused heart. Cytochemistry and biochemical and X-ray microanalysis.
- J. Slezak, N. Tribulova, P. Singal
- BiologyAmerican Journal of Pathology
- 1 September 1995
A significant increase in myocardial H2O2 during both the phase of ischemia and the first few minutes of reperfusion supports a stronger reaction on the sarcolemma and abluminal side of endothelial cells as well as vulnerability of these sites to oxidative stress injury.
Factors influencing chelator-stable, detergent-extractable, phorbol diester-induced membrane association of protein kinase C. Differences between Ca2+-induced and phorbol ester-stabilized membrane…
- R. Gopalakrishna, S. Barsky, T. Thomas, W. Anderson
- Biology, ChemistryJournal of Biological Chemistry
- 15 December 1986
Modulation of renal epithelial cell growth by glucosylceramide. Association with protein kinase C, sphingosine, and diacylglycerol.
- J. Shayman, G. Deshmukh, N. Radin
- Biology, ChemistryJournal of Biological Chemistry
- 5 December 1991
Endogenous antioxidant changes in the myocardium in response to acute and chronic stress conditions
Exogenous and/or exogenous increase in antioxidants might have a therapeutic potential in various pathological conditions which result from increased free radical production.
Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C
- W. Farrar, T. Thomas, W. Anderson
- BiologyNature
- 16 May 1985
Evidence that IL-3-receptor interaction stimulates the rapid and transient redistribution of protein kinase C from cytosol to plasma membrane in FDC-P1 cells is presented and it is suggested thatIL-3 and phorbol esters share a common feature of transmembrane signalling crucial for growth and differentiation.
Protein kinase C: subcellular redistribution by increased Ca2+ influx. Evidence that Ca2+-dependent subcellular redistribution of protein kinase C is involved in potentiation of beta-adrenergic…
- A. Ho, T. Thomas, C. Chik, W. Anderson, D. Klein
- BiologyJournal of Biological Chemistry
- 5 July 1988
Hormone- and tumor promoter-induced activation or membrane association of protein kinase C in intact cells.
- T. Thomas, R. Gopalakrishna, W. Anderson
- BiologyMethods in Enzymology
- 1987
Combination therapy with probucol prevents adriamycin-induced cardiomyopathy.
- P. Singal, N. Siveski-Iliskovic, M. Hill, T. Thomas, T. Li
- Medicine, BiologyJournal of Molecular and Cellular Cardiology
- 1 April 1995
Diminished Specific Activity of Cytosolic Protein Kinase C In Sciatic Nerve of Streptozocin-Induced Diabetic Rats and Its Correction by Dietary myo-Inositol
- Jean Kim, E. Rushovich, T. Thomas, T. Ueda, B. Agranoff, D. Greene
- Biology, ChemistryDiabetes
- 1 November 1991
The results suggest that altered MI metabolism may affect nerve PKC specific activity, and this alteration may play a role in reduced Na+-K+-ATPase activity and blunted regenerative response in diabetic nerve.
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