T. Thomas

Publications29
h-index12
Citations1,617
Highly Influential Citations28
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Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes
TLDR
The results suggest that kinase activation is involved and the data provide the first demonstration of a synergistic interaction between Ca2+-phospholipid-dependent protein kinase (protein kinase C) and neurotransmitter-dependent stimulation of cyclic AMP. Expand
Hydrogen peroxide changes in ischemic and reperfused heart. Cytochemistry and biochemical and X-ray microanalysis.
TLDR
A significant increase in myocardial H2O2 during both the phase of ischemia and the first few minutes of reperfusion supports a stronger reaction on the sarcolemma and abluminal side of endothelial cells as well as vulnerability of these sites to oxidative stress injury. Expand
Factors influencing chelator-stable, detergent-extractable, phorbol diester-induced membrane association of protein kinase C. Differences between Ca2+-induced and phorbol ester-stabilized membrane…
TLDR
TPA-stabilized membrane binding of protein kinase C differs in several aspects from the previously reported Ca2+-induced reversible binding, which is temperature dependent, relatively high in the plasma membrane-enriched fraction, saturable at physiological levels of protein Kinase C, and exhibits trypsin-insensitive membrane binding sites. Expand
Hormone- and tumor promoter-induced activation or membrane association of protein kinase C in intact cells.
TLDR
Assays allow the design of experiments with intact cells to determine the possible involvement (activation) of protein kinase C in modulating the biological responses to hormones, tumor promoters, and other extracellular agents. Expand
Modulation of renal epithelial cell growth by glucosylceramide. Association with protein kinase C, sphingosine, and diacylglycerol.
TLDR
An association between glucosylceramide levels, PKC activity, and cell growth is demonstrated, and the elevation in endogenous sphingosine was probably insufficient to account for the decrease in PKC, considering the high level of diacylglycerol in the cells. Expand
Altered cytosol/membrane enzyme redistribution on interleukin-3 activation of protein kinase C
TLDR
Evidence that IL-3-receptor interaction stimulates the rapid and transient redistribution of protein kinase C from cytosol to plasma membrane in FDC-P1 cells is presented and it is suggested thatIL-3 and phorbol esters share a common feature of transmembrane signalling crucial for growth and differentiation. Expand
Protein kinase C: subcellular redistribution by increased Ca2+ influx. Evidence that Ca2+-dependent subcellular redistribution of protein kinase C is involved in potentiation of beta-adrenergic…
TLDR
It was found that a very close correlation exists between translocation of protein kinase C by phenylephrine, K+, and A23187 and their ability to potentiate beta-adrenergic stimulation of cAMP and cGMP accumulation and this provides strong support to the proposal that translocations of protein Kinase C is required for potentiation of beta- adrenoceptor stimulation of pinealocytes. Expand
Combination therapy with probucol prevents adriamycin-induced cardiomyopathy.
TLDR
It has been discovered that probucol, a lipid lowering agent and potent antioxidant, provides complete protection against adriamycin-induced cardiomyopathy in rats without interfering with the anti-tumor properties of this antibiotic. Expand
Endogenous antioxidant changes in the myocardium in response to acute and chronic stress conditions
TLDR
Exogenous and/or exogenous increase in antioxidants might have a therapeutic potential in various pathological conditions which result from increased free radical production. Expand
Probucol improves antioxidant activity and modulates development of diabetic cardiomyopathy.
TLDR
Evidence is provided that diabetic cardiomyopathy is associated with an antioxidant deficit, and a better cardiac function due to treatment with probucol may be related to the improved insulin levels as well as maintenance of the antioxidant status of the heart. Expand
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