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The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.
Flavonoids are nearly ubiquitous in plants and are recognized as the pigments responsible for the colors of leaves, especially in autumn. They are rich in seeds, citrus fruits, olive oil, tea, andExpand
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Acute stress increases permeability of the blood–brain-barrier through activation of brain mast cells
Disruption of the blood-brain-barrier (BBB) is important in the pathophysiology of various inflammatory conditions of the central nervous system (CNS), such as multiple sclerosis (MS), in whichExpand
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Differential release of mast cell mediators and the pathogenesis of inflammation
Summary:  Mast cells are well known for their involvement in allergic and anaphylactic reactions, during which immunoglobulin E (IgE) receptor (FcɛRI) aggregation leads to exocytosis of the contentExpand
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Mast cells: the Jekyll and Hyde of tumor growth.
Abstract Mast cells accumulate in the stroma surrounding certain tumors, especially mammary adenocarcinoma, and molecules they secrete could benefit the tumor. These include heparin, interleukin-8Expand
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Mast cell involvement in interstitial cystitis: a review of human and experimental evidence.
Interstitial cystitis (IC) is a heterogeneous syndrome of unknown etiology. Altered bladder glycosaminoglycans lining and bladder mastocytosis have been documented in IC. The objective of thisExpand
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Human Mast Cells Express Corticotropin-Releasing Hormone (CRH) Receptors and CRH Leads to Selective Secretion of Vascular Endothelial Growth Factor1
Mast cells are critical for allergic reactions, but also for innate or acquired immunity and inflammatory conditions that worsen by stress. Corticotropin-releasing hormone (CRH), which activates theExpand
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The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis.
Current evidence from clinical and laboratory studies confirms that mast cells play a central role in the pathogenesis and pathophysiology of interstitial cystitis (IC). In this article, we focus onExpand
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IL-10, an inflammatory/inhibitory cytokine, but not always.
IL-10 has been previously called cytokine synthesis inhibiting factor, produced mostly by Th2 cells, macrophages and CD8+ cell clones. IL-10 is capable of inhibiting the synthesis of severalExpand
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Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation.
PURPOSE Gut microbiota regulate intestinal function and health. However, mounting evidence indicates that they can also influence the immune and nervous systems and vice versa. This article reviewsExpand
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Mast cells: the immune gate to the brain.
Mast cells were originally considered wandering histiocytes, but are now known to derive from the bone marrow and enter the tissues as immature or precursor cells which then differentiate underExpand
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