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The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.
- E. Middleton, C. Kandaswami, T. Theoharides
- Chemistry, Medicine
- Pharmacological reviews
- 1 December 2000
Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing. Expand
Acute stress increases permeability of the blood–brain-barrier through activation of brain mast cells
It is shown that acute stress by immobilization increased permeability of rat BBB to intravenous 99Technetium gluceptate (99Tc) and induced activation of mast cells in diencephalon, the site where most mast cells are found in the rat brain. Expand
Differential release of mast cell mediators and the pathogenesis of inflammation
- T. Theoharides, D. Kempuraj, M. Tagen, P. Conti, D. Kalogeromitros
- Biology, Medicine
- Immunological reviews
- 1 June 2007
Understanding this process could help develop mast cell inhibitors of selective mediator release with novel therapeutic applications, as it appears to involve de novo synthesis of mediators, such as interleukin‐6 and vascular endothelial growth factor, with release through secretory vesicles similar to those in synaptic transmission. Expand
Mast cell involvement in interstitial cystitis: a review of human and experimental evidence.
The literature on bladder mastocytosis and mast cell activation in IC is critically reviewed with particular reference to staining methodology, tryptase immunoreactivity, and electron microscopy, with particular emphasis on morphologic evidence of mast cell increase and activation. Expand
Mast cells: the Jekyll and Hyde of tumor growth.
It is proposed that beneficial and destructive mediators are either released from separate granules or much smaller vesicles regulated by selectively distinct signals, such as tumor-derived oxidized polyamines or nitric oxide from new endothelial cells. Expand
Human Mast Cells Express Corticotropin-Releasing Hormone (CRH) Receptors and CRH Leads to Selective Secretion of Vascular Endothelial Growth Factor1
- Jing Cao, N. Papadopoulou, +4 authors T. Theoharides
- Biology, Medicine
- The Journal of Immunology
- 15 June 2005
This work reports the first evidence that mast cells express functional CRH receptors and that CRH can induce VEGF secretion selectively, which could be involved in chronic inflammatory conditions associated with increased V EGF, such as arthritis or psoriasis. Expand
The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis.
Identifying the patients with IC who have mast cell proliferation and activation will enable us to address this aspect of disease pathophysiology in these individuals with targeted pharmacotherapy to inhibit mast cell activation and mediator release. Expand
IL-10, an inflammatory/inhibitory cytokine, but not always.
It is reported for the first time that IL-10 fails to inhibit tryptase and IL-6 from human mast cell-1 and human umbilical cord blood-derived mast cells. Expand
Mast cells: the immune gate to the brain.
- T. Theoharides
- Biology, Medicine
- Life sciences
Information suggests that mast cells may serve as a link between the immune, endocrine and nervous systems and could have an important role in the access of lymphocytes and pathogens to the brain. Expand
Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation.
- A. Petra, S. Panagiotidou, E. Hatziagelaki, J. M. Stewart, P. Conti, T. Theoharides
- Clinical therapeutics
- 1 May 2015
Recognition of the relationship between the MGB axis and the neuroimmune systems provides a novel approach for better understanding and management of these disorders. Expand