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Long-term potentiation and memory.
- T. Teyler
- BiologyInternational journal of neurology
A hypothesis will be examined that long-term potentiation in hippocampus and neocortex may subserve information storage in the central nervous system.
The available evidence suggests that L TP does occur in conjunction with behavioral learning-although whether it is necessary and sufficient is far from certain.
Two components of long-term potentiation induced by different patterns of afferent activation
It is reported that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.
Two forms of long-term potentiation in area CA1 activate different signal transduction cascades.
Results suggest a differential involvement of H-7-sensitive serine/threonine kinases and tyrosine kinase inhibitors in the two forms of LTP, which reached comparable magnitudes despite their different induction parameters and developmental kinetics.
The hippocampal memory indexing theory.
It is asserted that the reactivation of the stored hippocampal memory index will serve to also reactivate the associated unique array of neocortical areas and thus will result in a memorial experience.
Aging differentially alters forms of long-term potentiation in rat hippocampal area CA1.
The results suggest that aging causes a shift in synaptic plasticity from NMDAR-dependent mechanisms to VDCC- dependent mechanisms, which may help explain age-related deficits in learning and memory.
Long‐term potentiation of human visual evoked responses
- T. Teyler, J. Hamm, W. Clapp, Blake W. Johnson, M. Corballis, I. Kirk
- BiologyThe European journal of neuroscience
- 1 April 2005
The ability to elicit LTP from non‐surgical patients will provide a human model system allowing the detailed examination of synaptic plasticity in normal subjects and may have future clinical applications in the assessment of cognitive disorders.
The hippocampal indexing theory and episodic memory: Updating the index
The hippocampal memory index theory has aged very well and its core ideas can be seen in many contemporary theories and there is a wealth of data that support this conceptual framework.
Induction of orientation-specific LTP-like changes in human visual evoked potentials by rapid sensory stimulation
Spatial frequency-specific potentiation of human visual-evoked potentials
- N. McNair, W. Clapp, J. Hamm, T. Teyler, M. Corballis, I. Kirk
- Biology, PsychologyNeuroreport
- 15 May 2006
The results suggest that the long-term potentiation effect induced by the sensory tetanus is isolated to a discrete neural population in the visual cortex.