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Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease.
There are no plasma biomarkers specific for GVHD of the gastrointestinal (GI) tract, the GVHD target organ most associated with nonrelapse mortality (NRM) following hematopoietic cell transplantationExpand
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Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease.
Chronic graft-versus-host disease (GVHD) is the most common cause of poor long-term outcomes after allogeneic bone marrow transplantation (BMT), but the pathophysiology of chronic GVHD still remainsExpand
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LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation.
Acute graft-versus-host disease (GVHD) and leukemic relapse remain the two major obstacles to successful outcomes after allogeneic bone marrow transplantation (BMT). Recent studies have demonstratedExpand
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The Pathophysiology of Acute Graft-versus-Host Disease
The pathophysiology of acute graft-versus-host disease (GVHD) is a complex process that can be conceptualized in three phases. In the first phase, high-dose chemoradiotherapy causes damage to hostExpand
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Enhanced allostimulatory activity of host antigen-presenting cells in old mice intensifies acute graft-versus-host disease.
Older bone marrow transplantation (BMT) recipients are at heightened risk for acute graft-versus-host disease (GVHD) after allogeneic BMT, but the causes of this association are poorly understood.Expand
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Host Dendritic Cells Alone Are Sufficient to Initiate Acute Graft-versus-Host Disease1
Alloantigen expression on host APCs is essential to initiate graft-vs-host disease (GVHD); however, critical APC subset remains to be elucidated. We compared the ability of dendritic cells (DCs) andExpand
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Central nervous system involvement in adult T‐cell leukemia/lymphoma
Central nervous system (CNS) involvement was reviewed in 99 patients with adult T‐cell leukemia/lymphoma (ATLL). Fifteen episodes of CNS involvement developed in ten of 99 patients (10.1%); nine hadExpand
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Growth changes in morphological and mechanical properties of human patellar tendon in vivo.
The purpose of this study was to compare the morphological and mechanical properties of the human patellar tendon among elementary school children (prepubertal), junior high school studentsExpand
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Role of CXCR3-induced donor T-cell migration in acute GVHD.
OBJECTIVE The chemokine receptor CXCR3 has an important role in the migration of effector T cells. To investigate the role of CXCR3 on donor cells in acute graft vs host disease (GVHD) we used aExpand
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Understanding the alloresponse: new approaches to graft-versus-host disease prevention.
Graft-versus-host disease (GVHD) has been the primary limitation to the wider application of allogeneic bone marrow transplantation (BMT). GVHD occurs when donor T cells react to host antigens onExpand
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