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KATP channel modulation in working rat hearts with coronary occlusion: effects of cromakalim, cicletanine, and glibenclamide.
OBJECTIVES We studied the effects of ATP-sensitive potassium channel (KATP) modulation on ischemic cardiac performance and reperfusion-induced ventricular fibrillation (VF), and assessed theExpand
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Regional localization of patterned spontaneous discharges during maturation in culture of fetal mouse medulla and spinal cord explants.
Development and regional localization of patterned spontaneous bioelectric activities, recorded extracellularly, were studied in cultures of frontal sections of spinal cord and medulla, explantedExpand
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α2‐Adrenoceptor Changes During Cerebral Ageing. The Effect of Ginkgo biloba Extract
Abstract— [3H]Rauwolscine binding to α2‐adrenoceptors in cerebral cortex and hippocampus membranes of young (4 months) and aged (24 months) Wistar rats has been investigated. In aged rats, BmaxExpand
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Efficacy and tolerance of cicletanine, a new antihypertensive agent: overview of 1226 treated patients.
The data gathered from 1226 patients for 20 controlled therapeutic studies performed during the phase-III development of cicletanine, a new antihypertensive agent, were pooled in a computerizedExpand
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UV-C irradiation-induced peroxidative degradation of microsomal fatty acids and proteins: protection by an extract of Ginkgo biloba (EGb 761).
After exposure of rat liver microsomes to UV-C irradiation, analysis of membrane fatty acids by gas chromatography confirmed that EGb 761, a drug containing a dosed and standardized extract of GinkgoExpand
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Cicletanine Improves Myocardial Function Deteriorated by Ischemia/Reperfusion in Isolated Working Rat Hearts
Summary The effect of cicletanine, a novel furopyridine antihypertensive drug was compared with that of nitren-dipine, a dihydropyridine slow calcium channel blocker, on cardiac function andExpand
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Cicletanine attenuates overdrive pacing‐induced global myocardial ischemia in rabbits: possible role of cardiac cyclic nucleotides
BackgroundThis study examined whether cicletanine, an antihypertensive drug with cGMP phosphodiesterase inhibitory effect, could alleviate ventricular overdrive pacing-induced myocardial ischemia inExpand
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Effect of cicletanine on reperfusion-induced arrhythmias and myocardial ion contents: a comparison with furosemide.
We studied the effects of cicletanine, a furopyridine antihypertensive drug, and furosemide, a loop diuretic, on ventricular arrhythmias, such as sustained ventricular fibrillation (VF) andExpand
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Protective Effect of Cicletanine on Hypertension‐Induced Decreases in the Renal Kallikrein‐Kinin and Prostaglandin Systems in Stroke‐Prone Spontaneously Hypertensive Rats
Summary: We investigated the effect of two oral (p.o.) doses of cicletanine (5 and 30 mg/kg/day) for 4 weeks on urinary excretion (UKE), renal concentration (RKC) of kallikrein, and prostaglandin E2Expand
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