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Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiotaExpand
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy. Expand
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Using a rational approach to isolate CD4+FOXP3+ regulatory T (Treg)-cell-inducing bacterial strains from the human indigenous microbiota may allow for tailored therapeutic manipulation of human immune disorders. Expand
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells
It is shown that adhesion of microbes to intestinal epithelial cells (ECs) is a critical cue for Th17 induction, and a mixture of 20 bacterial strains, which were selected and isolated from fecal samples of a patient with ulcerative colitis on the basis of their ability to cause a robust induction of Th17 cells in the mouse colon, exhibited EC-adhesive characteristics. Expand
Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers
Depletion of FOXP3hi Treg cells from tumor tissues, which would augment antitumor immunity, could thus be used as an effective treatment strategy for CRCs and other cancers, whereas strategies that locally increase the population ofFOXP3lo non-Treg cells could be used to suppress or prevent tumor formation. Expand
Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation
Gut reasons to brush your teeth Some gut conditions, such as inflammatory bowel disease (IBD), ulcerative colitis, and Crohn's disease (CD), are associated with imbalances in the gut microbeExpand
Development and maintenance of intestinal regulatory T cells
These cells have pivotal roles in the suppression of immune responses against harmless dietary antigens and commensal microorganisms and provide important insights into disease-relevant host–microorganism interactions. Expand
A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
A consortium of 11 bacterial strains from the healthy human gut microbiota can strongly induce interferon-γ-producing CD8 T cells in the intestine, and enhance both resistance to bacterial infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models. Expand
Lactococcus lactis subsp. cremoris FC alleviates symptoms of colitis induced by dextran sulfate sodium in mice.
Probiotics have been used to treat human gastrointestinal inflammations including inflammatory bowel disease (IBD). However, the exact mechanisms by which probiotics act to protect against intestinalExpand
In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells.
Results indicated that this co-culture model could imitate the gut inflammation in vivo, and fucoidan, sulphated polysaccharides from brown algae, was employed as a candidate of evolution and added to the apical side of this model. Expand