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Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
The gastrointestinal tract of mammals is inhabited by hundreds of distinct species of commensal microorganisms that exist in a mutualistic relationship with the host. How commensal microbiotaExpand
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Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Bacteria of the genus Clostridium promote the induction of suppressor T cells in the colons of mice. CD4+ T regulatory cells (Tregs), which express the Foxp3 transcription factor, play a criticalExpand
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Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Manipulation of the gut microbiota holds great promise for the treatment of inflammatory and allergic diseases. Although numerous probiotic microorganisms have been identified, there remains aExpand
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Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells
Intestinal Th17 cells are induced and accumulate in response to colonization with a subgroup of intestinal microbes such as segmented filamentous bacteria (SFB) and certain extracellular pathogens.Expand
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Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation
Gut reasons to brush your teeth Some gut conditions, such as inflammatory bowel disease (IBD), ulcerative colitis, and Crohn's disease (CD), are associated with imbalances in the gut microbeExpand
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Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers
CD4+ T cells that express the forkhead box P3 (FOXP3) transcription factor function as regulatory T (Treg) cells and hinder effective immune responses against cancer cells. Abundant Treg cellExpand
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Development and maintenance of intestinal regulatory T cells
Gut-resident forkhead box P3 (FOXP3)+CD4+ regulatory T cells (Treg cells) are distinct from those in other organs and have gut-specific phenotypes and functions. Whereas Treg cells in other organsExpand
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In vitro model to estimate gut inflammation using co-cultured Caco-2 and RAW264.7 cells.
A system for assessing the anti-inflammatory effect of food factors was developed by establishing a co-culture system with intestinal epithelial Caco-2 cells (apical side) and macrophage RAW264.7Expand
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Lactococcus lactis subsp. cremoris FC alleviates symptoms of colitis induced by dextran sulfate sodium in mice.
Probiotics have been used to treat human gastrointestinal inflammations including inflammatory bowel disease (IBD). However, the exact mechanisms by which probiotics act to protect against intestinalExpand
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A defined commensal consortium elicits CD8 T cells and anti-cancer immunity
There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentiallyExpand
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