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Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia.
Chronic hypoxia causes pulmonary hypertension and right ventricular hypertrophy associated with pulmonary vascular remodeling. Because hypoxia might promote generation of oxidative stress in vivo, weExpand
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Alveolar liquid and protein clearance from normal dog lungs.
To determine whether liquid and protein clearance from the air spaces and lungs of anesthetized and unanesthetized dogs is the same as in sheep, we quantified these variables at three different timeExpand
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Evidence of acute inflammatory response in reexpansion pulmonary edema.
We analyzed edema fluid in two cases of reexpansion pulmonary edema during thoracotomy. High value of the fluid to plasma protein concentration ratio indicates an increase in pulmonary microvascularExpand
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Prognostic assessment of 1310 patients with non-small-cell lung cancer who underwent complete resection from 1980 to 1993.
OBJECTIVE The TNM staging system of lung cancer is widely used as a guide for estimating prognosis and selecting treatment modality. In 1997, the International Union Against Cancer and the AmericanExpand
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MDM2 expression is associated with progress of disease and WAF1 expression in resected lung cancer.
Although MDM2, p21/WAF1, and p53 are considered as regulating each other based on in vitro studies, the relation in human lung cancer is not fully understood. The expressions of these proteins wereExpand
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Hyaluronic acid enhances cell migration and invasion via the YAP1/TAZ-RHAMM axis in malignant pleural mesothelioma
Most malignant mesotheliomas (MPMs) frequently show activated forms of Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ), which transcriptionally regulatesExpand
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Endothelial Barrier Strengthening by Activation of Focal Adhesion Kinase*
Endothelial cell barrier (EC) properties regulate blood tissue fluid flux. To determine the role of endothelial-matrix interactions in barrier regulation, we induced cell shrinkage by exposingExpand
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Expression of Bcl-2, Bax, and p53 proteins in carcinogenesis of squamous cell lung cancer.
BACKGROUND Apoptosis is regulated by many genes, including bcl-2, p53, and bcl-2 family genes. The expression of Bcl-2, p53, and Bax in very early lung cancers or precancer lesions is not been fullyExpand
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Vasoactive intestinal peptide causes nitric oxide-dependent pulmonary vasodilation in isolated rat lung.
Vasoactive intestinal peptide (VIP) is one of the chief neurotransmitters of nonadrenergic noncholinergic nerve fibers. In this study, we investigated the effect of VIP on the pulmonary circulationExpand
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