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Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model.
TLDR
The present method has advantages over the high-performance liquid Chromatography/electrochemical detector, gas chromatography/mass spectrometry, and 32P-postlabeling methods in that it allows localization of 8-OHdG to be specified without the risk of artifactual production of 8 -OHdGs during the DNA extraction and hydrolytic processes.
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin.
TLDR
Results indicate that diosmin and hesperidin, both alone and in combination, act as a chemopreventive agent against colon carcinogenesis, and such effects may be partly due to suppression of cell proliferation in the colonic crypts, although precise mechanisms should be clarified.
Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress-induced renal injury in mice.
TLDR
The results suggest that U1 is converted toTHU1 in vivo and that THU1 is a more promising chemopreventive agent.
A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells.
TLDR
Results suggest that cMOAT levels are inversely correlated with those of glutathione, and that c MOAT and its related genes may be involved in the sensitivity of cells to certain anticancer agents.
Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol.
TLDR
It is suggested that dietary I3C inhibits spontaneous occurrence of endometrial adenocarcinoma as well as preneoplastic lesions in Donryu rats and may be due to its induction of estradiol 2-hydroxylation.
Suppression of tumor promoter-induced oxidative stress and inflammatory responses in mouse skin by a superoxide generation inhibitor 1'-acetoxychavicol acetate.
TLDR
The results suggested that ROS from leukocytes including O2- plays an important role for continuous and excessive production of chemotactic factors, leading to chronic inflammation and hyperplasia, which are inhibitable by ACA.
Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells.
TLDR
Results indicate that renal tubular cells exposed to high protein load suffer from ER stress, and ER stress may subsequently lead to tubular damage by activation of caspase-12.
Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.
TLDR
The results indicate that the pancreatic beta-cells of GK rats are oxidatively stressed, and that chronic hyperglycemia might be responsible for the oxidative stress observed in the pancreato-cells.
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-carotene.
TLDR
Feeding of curcumin and beta-carotene during the initiation and postinitiation phases and hesperidin at the initiation stage caused a significant reduction in the frequency of tongue carcinoma, and dietary administration of these compounds significantly decreased the labeling index of bromodeoxyuridine and the number and area of silver-stained nucleolar organizer region proteins per cell nucleus that are proliferation biomarkers, of the tongue squamous epithelium.
Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast.
TLDR
Immunohistochemical analyses of invasive ductal adenocarcinomas of the breast revealed that overexpression of AIK1 was observed in 94% of the cases, irrespective of the histopathological type, whereas the protein was not detected in normal ductal and lobular cells.
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