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Edaravone Attenuates Brain Edema and Neurologic Deficits in a Rat Model of Acute Intracerebral Hemorrhage
TLDR
Edaravone attenuates ICH-induced brain edema, neurologic deficits, and oxidative injury and reduces iron- and thrombin- induced brain injury, suggesting that it is a potential therapeutic agent for ICH.
Peritumoral Brain Edema in Intracranial Meningiomas: Effects of Radiological and Histological Factors
TLDR
Tumor infiltration into adjacent brain parenchyma and a pial-cortical blood supply are critical factors for the development of peritumoral brain edema among patients with meningiomas.
Proton magnetic resonance spectroscopy reflects cellular proliferative activity in astrocytomas
TLDR
Findings suggest that the Cho signal in proton MRS reflects cellular proliferation, and the Cho/Cr ratio correlated positively and the NAA/Cho ratio inversely with Ki-67 LI.
Correlation of biological aggressiveness assessed by 11C-methionine PET and hypoxic burden assessed by 18F-fluoromisonidazole PET in newly diagnosed glioblastoma
TLDR
Detailed volumetric and spatial information of viable hypoxic tissue assessed by 18F-fluoromisonidazole PET relative to neovascularization in Gd-enhanced MRI and tumour aggressiveness by L-methyl-11C-methionine (MET) PET in newly diagnosed GBMs is analysed.
Differences in the neuronal stem cells survival, neuronal differentiation and neurological improvement after transplantation of neural stem cells between mild and severe experimental traumatic brain
TLDR
The transplanted neurospheres could survive in the mild TBI animals, but not in the severe TBI group, and increases in the neurotrophic factors' mRNA were evident in the hippocampus on the ipsilateral side in the Mild TBI groups.
Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm.
TLDR
This study shows that CPA/P450 2B1 gene therapy represents a novel tumor-killing strategy that displays an expanded range of cytotoxic action both spatially and temporally within tumor cells and significantly potentiates the anticancer action of CPA when administered i.v.
Prognostic value of pretreatment 18F-FDG PET in patients with primary central nervous system lymphoma: SUV-based assessment
TLDR
Pretreatment FDG uptake may have a prognostic value in newly diagnosed PCNSL and the difference of the overall survival curve between the low MVD (<20) and high MVD (≥20) groups was statistically analyzed.
Correlation of l-methyl-11C-methionine (MET) uptake with l-type amino acid transporter 1 in human gliomas
TLDR
MET SUVmax correlates with LAT1 expression in the tumor in newly diagnosed gliomas, and use of MET-PET as a molecular target combined with anti-angiogenesis in glioma therapy should be addressed in future studies.
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