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Mutations of optineurin in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) has its onset in middle age and is a progressive disorder characterized by degeneration of motor neurons of the primary motor cortex, brainstem and spinal cord.Expand
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Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain
Fused in sarcoma (FUS) and TAR DNA-binding protein 43 (TDP-43) are RNA-binding proteins pathogenetically linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD),Expand
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The RNA Binding Protein TLS Is Translocated to Dendritic Spines by mGluR5 Activation and Regulates Spine Morphology
Neuronal dendrites, together with dendritic spines, exhibit enormously diverse structure. Selective targeting and local translation of mRNAs in dendritic spines have been implicated in synapseExpand
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Acute Physical Stress Elevates Mouse Period1 mRNA Expression in Mouse Peripheral Tissues via a Glucocorticoid-responsive Element*
In mammals, the circadian and stress systems (both centers of which are located in the hypothalamus) are involved in adaptation to predictable and unpredictable environmental stimuli, respectively.Expand
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A Novel ATP-dependent Inward Rectifier Potassium Channel Expressed Predominantly in Glial Cells (*)
We have isolated a novel inward rectifier K+ channel predominantly expressed in glial cells of the central nervous system. Its amino acid sequence exhibited 53% identity with ROMK1 and approximatelyExpand
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Transcriptional oscillation of canonical clock genes in mouse peripheral tissues
BackgroundThe circadian rhythm of about 24 hours is a fundamental physiological function observed in almost all organisms from prokaryotes to humans. Identification of clock genes has allowed us toExpand
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A light‐independent oscillatory gene mPer3 in mouse SCN and OVLT
A new member of the mammalian period gene family, mPer3, was isolated and its expression pattern characterized in the mouse brain. Like mPer1, mPer2 and Drosophila period, mPer3 has a dimerizationExpand
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  • Open Access
TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines
TLS (translocation in liposarcoma), an RNA-binding protein, was originally identified as a heterogeneous ribonuclear protein (hnRNP). Recently, we showed that TLS is localized in neuronal dendritesExpand
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  • Open Access
CHD8 haploinsufficiency results in autistic-like phenotypes in mice
Autism spectrum disorder (ASD) comprises a range of neurodevelopmental disorders characterized by deficits in social interaction and communication as well as by restricted and repetitive behaviours.Expand
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Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping
Significance Each day, over 50 billion synaptic signals, mediated by the neurotransmitter GABA, are sent between neurons in the central circadian pacemaker in the mammalian brain to time andExpand
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  • Open Access