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In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia.
It is suggested that hypoxia induced the release of Glut in NTS and that this effect was mediated by arterial chemosensory input.
Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma.
- Y. Kikuchi, S. Okabe, +4 authors T. Takishima
- MedicineThe New England journal of medicine
- 12 May 1994
Reduced chemosensitivity to hypoxia and blunted perception of dyspnea may predispose patients to fatal asthma attacks.
Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack.
Findings suggest that a marked increase in goblet cells of the airways is a feature characteristic of patients with BA who die of a severe acute attack.
Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure.
- M. Yanai, K. Sekizawa, T. Ohrui, H. Sasaki, T. Takishima
- MedicineJournal of applied physiology
- 1 March 1992
Observations suggest that peripheral airways are the predominant site of airflow obstruction, irrespective of the different pathogenesis of chronic airflow obstruction.
Phasic Blood Flow Velocity Pattern in Epimyocardial Microvessels in the Beating Canine Left Ventricle
- K. Ashikawa, H. Kanatsuka, T. Suzuki, T. Takishima
- Biology, MedicineCirculation research
- 1 December 1986
Findings indicate that the phasic blood flow pattern is markedly different in the subepimyocardial microvessels from that in the large epicardial artery and the septal artery.
Modification of human left ventricular relaxation by small-amplitude, phase-controlled mechanical vibration on the chest wall.
BACKGROUND Direct clinical manipulation to improve an impairment of left ventricular (LV) relaxation has not been reported. We investigated whether the LV relaxation rate in humans could be modulated…
Microvascular sites and mechanisms responsible for reactive hyperemia in the coronary circulation of the beating canine heart.
The results indicate that all arterial microvessels are responsible for reactive hyperemia after coronary artery occlusions of 20-30 seconds, but there is greater participation of vessels smaller than 100 microns in the early phase of reactiveyperemia.
Underdiagnosis and undertreatment of COPD in primary care settings
- Tsuneyuki Takahashi, M. Ichinose, H. Inoue, K. Shirato, T. Hattori, T. Takishima
- 1 December 2003
The aim of this study was to improve the detection of COPD in a primary care setting and to evaluate the subsequent management of patients by general practitioners.
Direct-writing recorder of the dose-response curves of the airway to methacholine. Clinical application.
A new device for examining the bronchial hyperresponsiveness by directly writing the dose-response curve of respiratory resistance (Rrs) during the continuous inhalation of the methacholine in stepwise incremental concentrations found that the Rrs began to increase at a certain threshold concentration of methamphetamine (bronchial sensitivity) and that it has a curvilinear slope.
Oxygen radicals produce airway constriction and hyperresponsiveness in anesthetized cats.
- U. Katsumata, M. Miura, +4 authors T. Takishima
- Chemistry, MedicineThe American review of respiratory disease
- 1 May 1990
The concept that oxygen radicals generated by xanthine-XO inhalation may induce bronchoconstriction and airway hyperresponsiveness is supported.