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Stress distribution in lungs: a model of pulmonary elasticity.
MEAD, JERE, TAMOTSU TAKISHIMA, AND DAVID LEITH. Stress distribution in lungs: a model of pulmonary elasticity. J. Appl. Physiol. 28(5) : 596-608. 1970.Although lungs are exposed to transpulmonary… Expand
In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia.
1. An attempt has been made to test the hypothesis that, in the caudal part of nucleus tractus solitarii (NTS) where carotid sinus nerve (CSN) afferents project, L‐glutamate (Glut) modulates the… Expand
Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma.
BACKGROUND Many deaths from attacks of asthma may be preventable. However, the difficulty in preventing fatal attacks is that not all the pathophysiologic risk factors have been identified. METHODS… Expand
Frequency dependence of flow resistance in patients with obstructive lung disease.
- G. Grimby, T. Takishima, W. Graham, P. Macklem, J. Mead
- The Journal of clinical investigation
- 1 June 1968
Total respiratory, pulmonary, and chest wall flow resistances were determined by means of forced pressure and flow oscillations (3-9 cps) superimposed upon spontaneous breathing in a group of… Expand
Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack.
To examine the changes in airways in bronchial asthma (BA) during an asthma attack causing death, we performed morphometric analysis of autopsied lungs from three outpatients who died of severe acute… Expand
Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure.
- M. Yanai, K. Sekizawa, T. Ohrui, H. Sasaki, T. Takishima
- Journal of applied physiology
- 1 March 1992
To partition the central and peripheral airway resistance in awake humans, a catheter-tipped micromanometer sensing lateral pressure of the airway was wedged into the right lower lobe of a 3-mm-ID… Expand
Phasic Blood Flow Velocity Pattern in Epimyocardial Microvessels in the Beating Canine Left Ventricle
- K. Ashikawa, H. Kanatsuka, T. Suzuki, T. Takishima
- Biology, Medicine
- Circulation research
- 1 December 1986
We quantitated phasic epimyocardial microcirculatory coronary blood flow velocity patterns in the beating left ventricle. Using a newly developed floating objective and high-speed cinematography, red… Expand
Modification of human left ventricular relaxation by small-amplitude, phase-controlled mechanical vibration on the chest wall.
BACKGROUND Direct clinical manipulation to improve an impairment of left ventricular (LV) relaxation has not been reported. We investigated whether the LV relaxation rate in humans could be modulated… Expand
Microvascular sites and mechanisms responsible for reactive hyperemia in the coronary circulation of the beating canine heart.
Our aim was to elucidate the site and mechanism responsible for reactive hyperemia in coronary circulation. In in vivo beating canine hearts, microvessels of the left anterior descending coronary… Expand
Underdiagnosis and undertreatment of COPD in primary care settings
- Tsuneyuki Takahashi, M. Ichinose, H. Inoue, K. Shirato, T. Hattori, T. Takishima
- 1 December 2003
Objective: The aim of this study was to improve the detection of COPD in a primary care setting and to evaluate the subsequent management of these patients by general practitioners.