T. Takishima

Publications816
h-index47
Citations10,674
Highly Influential Citations171
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In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia.
TLDR
It is suggested that hypoxia induced the release of Glut in NTS and that this effect was mediated by arterial chemosensory input.
Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma.
TLDR
Reduced chemosensitivity to hypoxia and blunted perception of dyspnea may predispose patients to fatal asthma attacks.
Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack.
TLDR
Findings suggest that a marked increase in goblet cells of the airways is a feature characteristic of patients with BA who die of a severe acute attack.
Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure.
TLDR
Observations suggest that peripheral airways are the predominant site of airflow obstruction, irrespective of the different pathogenesis of chronic airflow obstruction.
Phasic Blood Flow Velocity Pattern in Epimyocardial Microvessels in the Beating Canine Left Ventricle
TLDR
Findings indicate that the phasic blood flow pattern is markedly different in the subepimyocardial microvessels from that in the large epicardial artery and the septal artery.
Modification of human left ventricular relaxation by small-amplitude, phase-controlled mechanical vibration on the chest wall.
BACKGROUND Direct clinical manipulation to improve an impairment of left ventricular (LV) relaxation has not been reported. We investigated whether the LV relaxation rate in humans could be modulated…
Microvascular sites and mechanisms responsible for reactive hyperemia in the coronary circulation of the beating canine heart.
TLDR
The results indicate that all arterial microvessels are responsible for reactive hyperemia after coronary artery occlusions of 20-30 seconds, but there is greater participation of vessels smaller than 100 microns in the early phase of reactiveyperemia.
Underdiagnosis and undertreatment of COPD in primary care settings
TLDR
The aim of this study was to improve the detection of COPD in a primary care setting and to evaluate the subsequent management of patients by general practitioners.
Direct-writing recorder of the dose-response curves of the airway to methacholine. Clinical application.
TLDR
A new device for examining the bronchial hyperresponsiveness by directly writing the dose-response curve of respiratory resistance (Rrs) during the continuous inhalation of the methacholine in stepwise incremental concentrations found that the Rrs began to increase at a certain threshold concentration of methamphetamine (bronchial sensitivity) and that it has a curvilinear slope.
Oxygen radicals produce airway constriction and hyperresponsiveness in anesthetized cats.
TLDR
The concept that oxygen radicals generated by xanthine-XO inhalation may induce bronchoconstriction and airway hyperresponsiveness is supported.
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