T. Takemoto

Publications243
h-index29
Citations3,795
Highly Influential Citations125
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Functional analysis of chicken Sox2 enhancers highlights an array of diverse regulatory elements that are conserved in mammals.
Sox2 expression marks neural and sensory primordia at various stages of development. A 50 kb genomic region of chicken Sox2 was isolated and scanned for enhancer activity utilizing embryo… Expand
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Tbx6-dependent Sox2 regulation determines neural vs mesodermal fate in axial stem cells
The classical view of neural plate development held that it arises from the ectoderm, after its separation from the mesodermal and endodermal lineages. However, recent cell-lineage-tracing… Expand
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Convergence of Wnt and FGF signals in the genesis of posterior neural plate through activation of the Sox2 enhancer N-1
The expression of the transcription factor gene Sox2 precisely marks the neural plate in various vertebrate species. We previously showed that the Sox2 expression prevailing in the neural plate of… Expand
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Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses
Sparing T cells from inhibition Programmed cell death 1 (PD-1) is an inhibitory receptor that normally keeps T cell immune responses in check. Immunotherapy targeting PD-1 has proven successful for… Expand
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Axial stem cells deriving both posterior neural and mesodermal tissues during gastrulation.
The posterior neural plate is primarily derived from the axial stem cells bipotential for neural and paraxial mesodermal development, which reside in the caudal lateral epiblast (CLE) of gastrulating… Expand
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Electroporation of Cas9 protein/sgRNA into early pronuclear zygotes generates non-mosaic mutants in the mouse.
The CRISPR/Cas9 system is a powerful tool for elucidating the roles of genes in a wide variety of organisms including mice. To obtain genetically modified embryos or mice by this method, Cas9 mRNA… Expand
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B1 and B2 Sox gene expression during neural plate development in chicken and mouse embryos: Universal versus species‐dependent features
Cumulative evidence now indicates pivotal roles for the group B1 Sox genes, Sox1, Sox2 and Sox3 in the genesis and development of neural primordia. Shared functions for the Sox1, Sox2 and Sox3… Expand
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Evolution of non-coding regulatory sequences involved in the developmental process: Reflection of differential employment of paralogous genes as highlighted by Sox2 and group B1 Sox genes
In higher vertebrates, the expression of Sox2, a group B1 Sox gene, is the hallmark of neural primordial cell state during the developmental processes from embryo to adult. Sox2 is regulated by the… Expand
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Terpenoids biotransformation in mammals III: Biotransformation of alpha-pinene, beta-pinene, pinane, 3-carene, carane, myrcene, and p-cymene in rabbits.
The biotransformation of (+)-, (-)-, and (+-)-alpha-pinenes, (-)-beta-pinene (nopinene), (-)-cis-pinane, (+)-3-carene, (-)-cis-carane, myrcene, and p-cymene in rabbits was investigated. The major… Expand
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Synthetic substrates for vertebrate collagenase.
Abstract Seven kinds of 2,4-dinitrophenyl derivatives of hexa- to octapeptides were prepared in order to find a synthetic substrate for vertebrate collagenase. Analysis of the degree of hydrolysis of… Expand
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