T. Takatsu

Publications61
h-index16
Citations758
Highly Influential Citations12
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Doxorubicin Overproduction in Streptomyces peucetius: Cloning and Characterization of the dnrU Ketoreductase anddnrV Genes and the doxA Cytochrome P-450 Hydroxylase Gene
ABSTRACT Doxorubicin-overproducing strains of Streptomyces peucetius ATCC 29050 can be obtained through manipulation of the genes in the region of the doxorubicin (DXR) gene cluster that…
A‐503083 A,B, E and F, Novel Inhibitors of Bacterial Translocase I, Produced by Streptomyces sp. SANK 62799
A-90289 A and B, new inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 60405
During the course of screening for translocase I inhibitors, the new liposidomycin-related compounds, A-90289 A and B, were isolated from a culture broth of Streptomyces sp. SANK 60405. The…
Colletoic Acid, a Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor from Colletotrichum gloeosporioides SANK 21404
TLDR
Colletoic acid, a novel 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, was found and isolated from the cultured broth of the producing fungus Colletotrichum gloeosporioides SANK 21404 to be a novel acorene-type sesquiterpene.
A-503083 A, B, E and F, novel inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 62799.
Novel nucleoside antibiotics were isolated from the cultured broth of the strain classified as Streptomyces sp. SANK 62799. The strain produced four novel capuramycin derivatives designated as…
Ascotricins A and B, novel antagonists of sphingosine-1-phosphate receptor 1 from Ascotricha chartarum Berk. SANK 14186
TLDR
Ascotricins A and B are novel S1P1 antagonists showing an inhibition activity toward HUVEC migration and are determined by various NMR experiments and by LC/MS and GC/MS analyses.
Trachyspic Acid, a New Metabolite Produced by Talaromyces trachyspermus, that Inhibits Tumor Cell Heparanase: Taxonomy of the Producing Strain, Fermentation, Isolation, Structural Elucidation, and…
Trachyspic acid, a new metabolite produced by Talaromyces trachyspermus, that inhibits tumor cell heparanase: taxonomy of the producing strain, fermentation, isolation, structural elucidation, and…
TLDR
Trachyspic acid, a new metabolite that inhibited heparanase, was isolated from the culture broth of Talaromyces trachyspermus SANK 12191 as a tricarboxylic acid derivative containing a spiroketal.
1100-50, a novel nematocide from Streptomyces lavendulae SANK 64297.
Synthesis and antimycobacterial activity of capuramycin analogues. Part 1: substitution of the azepan-2-one moiety of capuramycin.
Capuramycin analogues with a variety of substituents in place of the azepan-2-one moiety were synthesized from A-500359E and were tested for their translocase I inhibitory activity and in vitro…
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