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Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene.
Doxorubicin-overproducing strains of Streptomyces peucetius ATCC 29050 can be obtained through manipulation of the genes in the region of the doxorubicin (DXR) gene cluster that contains dpsH, theExpand
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A-90289 A and B, new inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 60405
During the course of screening for translocase I inhibitors, the new liposidomycin-related compounds, A-90289 A and B, were isolated from a culture broth of Streptomyces sp. SANK 60405. TheExpand
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A-503083 A, B, E and F, novel inhibitors of bacterial translocase I, produced by Streptomyces sp. SANK 62799.
Novel nucleoside antibiotics were isolated from the cultured broth of the strain classified as Streptomyces sp. SANK 62799. The strain produced four novel capuramycin derivatives designated asExpand
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Rustmicin, a new macrolide antibiotic active against wheat stem rust fungus.
Rustmicin, a new antibiotic active against the wheat stem rust fungus, was isolated from a cultured broth of Micromonospora chalcea 980-MC1. Rustmicin showed strong inhibitory activity against theExpand
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Colletoic Acid, a Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor from Colletotrichum gloeosporioides SANK 21404
Colletoic acid, a novel 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, was found and isolated from the cultured broth of the producing fungus Colletotrichum gloeosporioides SANK 21404.Expand
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Ogipeptins, novel inhibitors of LPS: physicochemical properties and structural elucidation
In the course of our screening program for inhibitors of lipopolysaccharide binding to cellular receptor CD14, a potent inhibitory activity was detected in the cultured broth of Pseudoalteromonas sp.Expand
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Ascotricins A and B, novel antagonists of sphingosine-1-phosphate receptor 1 from Ascotricha chartarum Berk. SANK 14186
Ascotricins A and B were isolated as novel sphingosine-1-phosphate receptor 1 (S1P1) antagonists from a cultured broth of a fungus identified as Ascotricha chartarum Berk. SANK 14186. The twoExpand
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