T. Takamura

Publications3
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Citations48
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Synthesis and biological evaluation of substituted benzenesulfonamides as novel potent membrane-bound phospholipase A2 inhibitors.
TLDR
A novel series of 4-[N-methyl-N-[(E)-3-[4-(methylsulfonyl)phenyl]-2- propenoyl]amino]benzenesulfonamides has been prepared and evaluated as membrane-bound phospholipase A2 inhibitors and the optimum potency was realized with the N-(phenylalkyl)piperidine derivatives 3 and 4.
Preferential hydrolysis of phosphatidylethanolamine in rat ischemic heart homogenates during in vitro incubation.
TLDR
Findings indicate that the type II phospholipase A2 activity may be involved in the breakdown of endogenous PE in ischemic heart homogenates, which ischemia induced by occlusion of the left main coronary artery.
Studies on the induced synthesis of maleate cis-trans isomerase by malonate: Part III. Purification and properties of maleate cis-trans isomerase induced by malonate
TLDR
The enzyme was most active at pH value around 8.3 and was stable over the range of pH 5.0 to 7.0 in the presence of dithiothreitol for a few weeks, but in the absence of it, the enzyme activity was markedly decreased, especially in the alkaline region.