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Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
It is shown that mice lacking immunoreceptor tyrosine-based activation motif (ITAM)-harbouring adaptors, Fc receptor common γ subunit (FcRγ) and DNAX-activating protein (DAP)12, exhibit severe osteopetrosis owing to impaired osteoclast differentiation.
Roles of Fc receptors in autoimmunity
- T. Takai
- Biology, MedicineNature Reviews Immunology
- 1 August 2002
An overview of the mechanisms of FcR-based immune regulation is provided and how autoimmune disease might result from its dysfunction is described.
FcR γ chain deletion results in pleiotrophic effector cell defects
Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12.
The identification of the first molecular marker of mouse natural interferon-producing cells (IPCs), a novel member of the sialic acid-binding immunoglobulin (Ig)-like lectin (Siglec) family termed Siglec-H, which supports a model in which engagement of DNAX-activation protein 12 (DAP12)-associated receptors with antibodies or low avidity endogenous ligands interferes with TLR-mediated cellular activation.
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway
The CaMKIV-CREB pathway biphasically functions to regulate the transcriptional program of osteoclastic bone resorption, by not only enhancing induction of NFATc1 but also facilitating NFAT c1-dependent gene regulation once its expression is induced.
Fc Receptors and Their Role in Immune Regulation and Autoimmunity
- T. Takai
- Biology, MedicineJournal of Clinical Immunology
This review is aimed at providing a current overview of the mechanism of Fc receptor-based immune regulation and the possible scenario of how autoimmune disease might result from their dysfunction.
FcR gamma chain deletion results in pleiotrophic effector cell defects.
Loss of gamma chain does not appear to perturb T cell development, since both thymic and peripheral T cell populations appear normal, and these mice represent an important tool for evaluating the role of these receptors in humoral and cellular immune responses.
Augmented humoral and anaphylactic responses in FcγRII-deficient mice
It is demonstrated that FcγRII acts as a general negative regulator of immune-complex-triggered activation in vivo for both the afferent and efferent limbs of the immune response.
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
Deletion of the gene encoding the Bcl-10 adaptor–binding partner CARD9 resulted in impaired myeloid cell activation of NF-κB signaling by several ITAM-associated receptors, and CARD9 was required for Toll-like receptor–induced activation of dendritic cells through the activation of mitogen-activated protein kinases.
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
It is shown that plexin-A1 associates with the triggering receptor expressed on myeloid cells-2 (Trem-2), linking semaphorin-signalling to the immuno-receptor tyrosine-based activation motif (ITAM)-bearing adaptor protein, DAP12, that presents a novel signalling mechanism for exerting the pleiotropic functions of semaphors.