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L-arginine-induced experimental pancreatitis.
Despite medical treatment, the lethality of severe acute pancreatitis is still high (20-30%). Therefore, it is very important to find good animal models to characterise the events of this severe… Expand
A new severe acute necrotizing pancreatitis model induced by l-ornithine in rats
Objective:Intraperitoneal administration of large doses of l-arginine is known to induce severe acute pancreatitis in rats. We therefore set out to determine whether metabolites of l-arginine… Expand
Effects of bile acids on pancreatic ductal bicarbonate secretion in guinea pig
Background and aims: Acute pancreatitis is associated with significant morbidity and mortality. Bile reflux into the pancreas is a common cause of acute pancreatitis and, although the bile can reach… Expand
Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats.
- A. Szabolcs, R. Reiter, +9 authors T. Takács
- World journal of gastroenterology
- 14 January 2006
AIM To determine the effect of melatonin pre- and post-treatment on the severity of L-arginine (L-Arg) -induced experimental pancreatitis in rats. METHODS Male Wistar rats (25) were divided into… Expand
Quality of life assessment after pancreatic enzyme replacement therapy in chronic pancreatitis.
- L. Czakó, T. Takács, +6 authors J. Lonovics
- Canadian journal of gastroenterology = Journal…
- 1 October 2003
GOALS To evaluate the quality of life (QoL) of patients with chronic pancreatitis before and after pancreatic enzyme replacement therapy in a prospective, multicentre, follow-up study. STUDY Two… Expand
Involvement of Oxygen-Derived Free Radicals in L-Arginine-Induced Acute Pancreatitis
This study was aimed at an assessment of the role of oxygen-derived free radicals in the pathogenesis of L-arginine (Arg)-induced acute pancreatitis in rat, by measuring the levels of malonyl… Expand
Plasma Concentrations of High-Mobility Group Box Protein 1, Soluble Receptor for Advanced Glycation End-Products and Circulating DNA in Patients with Acute Pancreatitis
Aims: High-mobility group box protein 1 (HMGB1), a late-acting proinflammatory cytokine, is secreted actively by inflammatory cells, and released passively from necrotic cells. From the aspect that… Expand
Heat shock proteins and the pancreas
- Z. Rakonczay, T. Takács, I. Boros, J. Lonovics
- Biology, Medicine
- Journal of cellular physiology
- 1 June 2003
Heat shock proteins (HSPs) are cytoprotective molecules that help to maintain the metabolic and structural integrity of cells. In this review, we briefly discuss the regulation and function of HSPs.… Expand
Beneficial effect of resveratrol on cholecystokinin-induced experimental pancreatitis.
- A. Szabolcs, I. Varga, +7 authors T. Takács
- Chemistry, Medicine
- European journal of pharmacology
- 17 February 2006
Resveratrol is a phytoalexin with strong antioxidant and anti-inflammatory effects reaching high concentrations in red wine. The aim of our study was to test the effects of resveratrol pretreatment… Expand
Spontaneous and cholecystokinin-octapeptide-promoted regeneration of the pancreas followingl-arginine-induced pancreatitis in rat
- P. Hegyi, T. Takács, K. Jármay, I. Nagy, L. Czakó, J. Lonovics
- International journal of pancreatology : official…
- 1 December 1997
SummaryConclusionInl-arginine (Arg)-induced pancreatitis, evidence of acute inflammation was observed on d 1–3. Continuous tissue atrophy became visible at the sites of previous pancreatic necrosis,… Expand