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The MLL recombinome of acute leukemias
TLDR
The precise localization of genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) was determined and several new TPGs were identified and two new MLL rearrangements are now characterized at the molecular level.
View on Springer
EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes
TLDR
The EuroFlow studies resulted in validated and flexible 8-color antibody panels for multidimensional identification and characterization of normal and aberrant cells, optimally suited for immunophenotypic screening and classification of hematological malignancies.
View on Nature
New insights to the MLL recombinome of acute leukemias
TLDR
The genetic network of reciprocal MLL gene fusions deriving from complex rearrangements is described for the first time, and the distribution of MLL breakpoints for clinical subtypes and fused translocation partner genes (TPGs) will be presented, including novel MLL fusion genes.
View on Nature
Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion
TLDR
These new insights will support the understanding of peripheral B cell regeneration after hematopoietic stem cell transplantation or B cell–directed antibody therapy, and the identification of defects in homeostatic or antigen-induced B cell proliferation in patients with common variable immunodeficiency or another antibody deficiency.
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A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial
View on Elsevier
Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study.
TLDR
It is believed that a combination of the inductive and antimicrobial properties of platelet-rich gel can improve the treatment of infected delayed healing and nonunion.
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Standardized flow cytometry for highly sensitive MRD measurements in B-cell acute lymphoblastic leukemia.
TLDR
The fully standardized EuroFlow BCP-ALL MRD strategy is applicable in >98% of patients with sensitivities at least similar to RQ-PCR, if sufficient cells (>4 × 106, preferably more) are evaluated.
View on PubMed
Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects
TLDR
The interpretation of RQ-PCR MRD data needs standardized criteria and reporting of MRDData needs international uniformity, and several European networks have now been established and common guidelines for data analysis and for reporting ofMRD data are being developed.
View on Nature
The MLL recombinome of acute leukemias in 2017
TLDR
This study provides a comprehensive analysis of the MLL recombinome in acute leukemia and demonstrates that the establishment of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.
View on Nature
Flow cytometric immunobead assay for the detection of BCR–ABL fusion proteins in leukemia patients
TLDR
A simple flow cytometric immunobead assay for detection of BCR–ABL fusion proteins in cell lysates, using a bead-bound anti-BCR catching antibody and a fluorochrome-conjugated anti-ABL detection antibody, which detects all types of B CR–ABl proteins in leukemic cells with high specificity and sensitivity.
View on Nature
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