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Regulation of intestinal epithelial permeability by tight junctions
  • T. Suzuki
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • 1 February 2013
The gastrointestinal epithelium forms the boundary between the body and external environment. It effectively provides a selective permeable barrier that limits the permeation of luminal noxiousExpand
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Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
We recently isolated a Krüppel-like zinc-finger transcription factor 5 (KLF5; also known as BTEB2 and IKLF), which is markedly induced in activated vascular smooth-muscle cells and fibroblasts. HereExpand
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Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappa B and induces nuclear translocation of transcription factor NF-kappa B proteins for
Human T-cell leukemia virus type I causes adult T-cell leukemia and tropical spastic paraparesis, and its regulator protein Tax has been implicated in the pathogenic activity of human T-cell leukemiaExpand
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Phosphorylation of Tyr-398 and Tyr-402 in Occludin Prevents Its Interaction with ZO-1 and Destabilizes Its Assembly at the Tight Junctions*
Occludin is phosphorylated on tyrosine residues during the oxidative stress-induced disruption of tight junction, and in vitro phosphorylation of occludin by c-Src attenuates its binding to ZO-1. InExpand
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Role of flavonoids in intestinal tight junction regulation.
  • T. Suzuki, H. Hara
  • Biology, Medicine
  • The Journal of nutritional biochemistry
  • 1 May 2011
The gastrointestinal tract provides a physical barrier to the diffusion of foreign materials from the lumen into the circulatory system. Impairment of the intercellular tight junction (TJ) shield,Expand
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Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions.
Protein kinases play an important role in the regulation of epithelial tight junctions. In the present study, we investigated the role of PKCζ (protein kinase Cζ) in tight junction regulation inExpand
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Kaempferol enhances intestinal barrier function through the cytoskeletal association and expression of tight junction proteins in Caco-2 cells.
Kaempferol, a natural flavonoid present in fruits, vegetables, and teas, provides beneficial effects for human health. We investigated the promotive effect of kaempferol on tight junction (TJ)Expand
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Trans-activator Tax of human T-cell leukemia virus type 1 enhances mutation frequency of the cellular genome.
Tax protein of human T-cell leukemia virus type 1 (HTLV-1) is a potent trans-activator of specific sets of target genes, and on the other hand, it is a trans-repressor of other sets of genes. It isExpand
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HTLV-1 Tax enhances NF-kappa B2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100.
Tax protein of HTLV-1 triggers transcriptional activation through enhancers, NF-kappa B binding site, 21-bp enhancer, and serum response element. Previously, we demonstrated binding of Tax toExpand
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HTLV-1 oncoprotein tax and cellular transcription factors.
Human T cell leukemia virus (HTLV) type 1 (Poiesz et al. 1980; Yoshida et al. 1982) has two regulatory genes, tax and rex, that control the viral gene expression and replication positively andExpand
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