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Preparation of zein microspheres conjugated with antitumor drugs available for selective cancer chemotherapy and development of a simple colorimetric determination of drugs in microspheres.
Zein microspheres conjugated with antitumor drugs (mitomycinc (MMC), daunomycin hydrochloride (DM), peplomycin sulfate (PEP) were prepared by using a dimethyl sulfoxide-H2O system, whereas some modifications were required for moderately and highly soluble drugs such as DM and PEP. Expand
Novel preparation of zein microspheres conjugated with PS-K available for cancer immunotherapy.
Microspheres which entrapped PS-K were prepared using Zein as a carrier matrix by a one-step or two-step process in dimethyl sulfoxide-H2O media and yielded a mono-dispersed preparation with a particle diameter less than 1 micron, which would be a suitable size for phagocytosis by macrophages. Expand
A new mycotoxin produced by Aspergillus clavatus.
Two strains of mycotoxin-producing fungi were proved to produce aflatoxins and new metabolite was isolated from one strain of Aspergillus clavatus found in wheat flour and named ascladiol. Expand
Metabolism of a new cardiotonic agent, (-)-alpha-(3,4-dimethoxyphenethylaminomethyl)-4-hydroxybenzyl alcohol (TA-064), in man. O-demethylation and ring hydroxylation.
A method is described for the determination of plasma concentration of (-)-alpha-(3,4-dimethoxyphenethylaminomethyl)-4-hydroxybenzyl alcohol (TA-064), a new, selectively inotropic cardiotonic agent,Expand
Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. III. Pharmacological evaluations and molecular modeling studies of optically active 4,5,6,7-tetrahydro-1H-benzimidazole derivatives.
The R- and S-enantiomers of the 4,5,6,7-tetrahydro-1H-benzimidazole derivatives 3-8 were prepared by optical resolution. Each R-isomer, except for 3, was almost two orders of magnitude more potentExpand
Metabolic incorporation of L-valine-[14C] into S-(2-carboxypropyl) glutathione and S-(2-carboxypropyl) cysteine in garlic.
It was proved that uniformly labeled L-valine-[14C] is incorporated into 2-carboxypropyl group of S-(2-carboxypropyl) glutathione and S-(2-carboxypropyl) cysteine in excised root of garlic. It wasExpand
Selective cytotoxicity of drug-monoclonal antibody conjugates against murine bladder tumor cells.
Antitumor agents including mitomycin C and methotrexate were coupled to monoclonal antibodies against murine bladder tumor cell line MBT-2 and cytotoxicity tests demonstrated that drug-antibody immune conjugates were 10 to 100 times more cytotoxic against antibody-reactive MBt-2 cells than nonimmune drug conjugate and showed a similar level of cytot toxicity against antibodies-nonreactive cells. Expand
Metabolism of S-(2-carboxypropyl) glutathione in rabbit.
2-(3-Pyridyl)thiazolidine-4-carboxamides. 1. Novel orally active antagonists of platelet-activating factor (PAF).
1-methyl-3-phenylbutyl)-4-[2-(3-pyridyl) thiazolidine-4-carbonyl]-piperazine fumarate (3al, YM264) was found to be one of the most potent PAF antagonists. Expand
In vitro metabolism of the new cardiotonic agent denopamine (TA-064) by rat and rabbit liver preparations. Oxidation, methylation, and glucuronidation.
The metabolic pathways of the cardiotonic agent denopamine, (-)-(R)-1-(p-hydroxyphenyl)-2-[(3,4-dimethoxyphenethyl)amino]ethanol, were studied in vitro with rat and rabbit liver preparations and glucuronidated in vitro by the rabbit liver microsomal fraction. Expand