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Continuous mild heat stress induces differentiation of mammalian myoblasts, shifting fiber type from fast to slow.
TLDR
Data suggest that CMHS induces a fast-to-slow fiber-type shift of mammalian myoblasts through PGC-1alpha, which is similar to that induced by EMTs for skeletal muscle repair following injury. Expand
Identification of cell-active lysine specific demethylase 1-selective inhibitors.
TLDR
The first small-molecule LSD1-selective inhibitors are identified and show in vivo H3K4-methylating activity and antiproliferative activity and should be useful as lead structures for anticancer drugs and as tools for studying the biological roles of LSD1. Expand
Structure-Activity Relationships of GPR120 Agonists Based on a Docking Simulation
TLDR
It is shown that a docking simulation using a GPR120 homology model might be useful to predict the agonistic activity of compounds. Expand
Photoinduced nitric oxide release from a hindered nitrobenzene derivative by two-photon excitation.
TLDR
This is the first account of a non-nitrosyl-chelated metal ion containing NO donor which can be controlled by the TPE technique. Expand
The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1.
TLDR
The data identify a novel pathway through which N-Myc causes neuroblastoma cell migration and invasion, and provide important evidence for further development of more potent JMJD1A/MALAT1 inhibitors for the prevention of tumor metastasis. Expand
An unexpected example of protein-templated click chemistry.
TLDR
In the course of an in situ click chemistry study on histone deacetylase (HDAC), acceleration of the AAC reaction by trace copper associated with the protein in a structurally sensitive manner is observed, which constitutes the first example of a Cu-protein complex catalyzing the AAC Reaction. Expand
Strychnine-insensitive binding of [3H]glycine to synaptic membranes in rat brain, treated with triton X-100
TLDR
Synaptic membranes of brain, treated with Triton X-100, are useful to detect the strychnine-insensitive binding of [3H]glycine and superior to untreated membranes in terms of the freedom from the confounding effects of some endogenous amino acids. Expand
Ruthenium-catalyzed hydration of 1-alkynes to give aldehydes: insight into anti-Markovnikov regiochemistry.
TLDR
The mechanism of the selective conversion of 1-alkynes to aldehydes by hydration was investigated by isolating organic and organometallic byproducts, deuterium-labeling experiments, and DFT calculations, which suggest the involvement of a metal-acyl intermediate with the original acetylenic hydrogen also bound to the metal center as a hydride. Expand
Intermolecular interactions and aggregation of fac-tris(2-phenylpyridinato-C2,N)iridium(III) in nonpolar solvents.
TLDR
H NMR spectra demonstrated a monomer-aggregate equilibrium which resulted in spectral shifts depending on solvent polarity, which was found to effectively decrease the luminescence lifetime via self-quenching with increasing fac-Ir(ppy)3 concentrations. Expand
Tissue-specific gene expression of heme oxygenase-1 (HO-1) and non-specific delta-aminolevulinate synthase (ALAS-N) in a rat model of septic multiple organ dysfunction syndrome.
TLDR
Findings suggest that heme oxygenase-1 and ALAS-N mRNA are regulated in a tissue-specific manner in a rat model of septic MODS. Expand
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