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Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells
In this paper we present keratin expression data that lend strong support to a model of corneal epithelial maturation in which the stem cells are located in the limbus, the transitional zone betweenExpand
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Strategies of epithelial repair: modulation of stem cell and transit amplifying cell proliferation.
Using double labeling techniques, we studied the replication of corneal epithelial stem cells that reside exclusively in the limbal zone, and their progeny transit amplifying cells. We show thatExpand
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Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies
Three monoclonal antibodies (AE1, AE2, and AE3) were prepared against human epidermal keratins and used to study keratin expression during normal epidermal differentiation. ImmunofluorescenceExpand
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Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins.
  • X. Wu, J. Lin, +4 authors T. Sun
  • Biology, Medicine
  • The Journal of biological chemistry
  • 6 May 1994
The asymmetric unit membrane (AUM) forms the apical plaques of mammalian urothelium and is believed to play a role in strengthening the urothelial apical surface thus preventing the cells fromExpand
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Selective Interactions of UPIa and UPIb, Two Members of the Transmembrane 4 Superfamily, with Distinct Single Transmembrane-domained Proteins in Differentiated Urothelial Cells (*)
The transmembrane 4 (TM4) superfamily contains many important leukocyte differentiation-related surface proteins including CD9, CD37, CD53, and CD81; tumor-associated antigens including CD63/ME491,Expand
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Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins
Although numerous hair proteins have been studied biochemically and many have been sequenced, relatively little is known about their in situ distribution and differential expression in the hairExpand
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The role of keratin subfamilies and keratin pairs in the formation of human epidermal intermediate filaments
The four major keratins of normal human epidermis (molecular mass 50, 56.5, 58, and 65-67 kD) can be subdivided on the basis of charge into two subfamilies (acidic 50-kD and 56.5-kD keratins vs.Expand
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Epidermal stem cells: properties, markers, and location.
  • R. Lavker, T. Sun
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 5 December 2000
Recent data indicate that stem cells exist in many tissues, including skeletal muscle, liver, and the central nervous system, some of them not known classically as having stem cells. The unexpectedExpand
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Large scale purification and immunolocalization of bovine uroplakins I, II, and III. Molecular markers of urothelial differentiation.
The differentiation of mammalian urothelium culminates in the formation of asymmetrical unit membrane (AUM). Using gradient centrifugation and detergent wash, we purified milligram quantities of AUMsExpand
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