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Rhythmicity of RNA polymerase activity and RNA levels in nuclei of rat cerebral cortex 1
THE ACTIVITY of RNA polymerase has been measured in a variety of mammalian tissues, including nuclei of brain cells (DUTTON and MAHLER, 1968). The possibility that RNA may be involved in neural… Expand
A semiautomated radioimmunoassay for mass screening of drugs of abuse.
- T. Sulkowski, G. D. Lathrop, J. Merritt, J. H. Landez, E. Noe
- Journal of forensic sciences
- 1 July 1975
A rapid, semiautomated radioimmunoassay system for detection of morphine, barbiturates, and amphetamines is described. The assays are applicable to large drug abuse screening programs. The heart of… Expand
Some comparative biochemical effects of 5-substituted congeners of salicylic acid.
Alterations of pineal gland biorhythms by N-methyl-3-piperidyl benzilate (JB336).
- J. H. Merritt, T. Sulkowski
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 March 1969
N-methyl-3-piperidyl benzilate (JB336), an anticholinergic psychotogenic agent, disrupts the circadian rhythm of serotonin in the rat pineal gland when the drug is administered at 0800 hours. The… Expand
Antiarrhythmic, hemodynamic and cardiac electrophysiological evaluation of N-(2,6-dimethylphenyl)-N'-[3-(1-methylethylamino)propyl]urea (Wy-42,362).
The antiarrhythmic, hemodynamic and cardiac electrophysiological effects of (Wy-42,362, in the following briefly called Wy) N-(2,6-dimethylphenyl)-N'-[3-(1-methylethylamino)propyl]urea were examined… Expand
Protection by the calcium antagonist Wy-47,037 against stress ulceration in the rat
Wy-47,037, a novel compound with both intracellular and extracellular calcium-blocking properties, was evaluated for its effects on cold/restraint stress induced ulceration in the rat. Wy-47,037… Expand
Inhibition of aromatic L-amino acid decarboxylation by decaborane.
The effect of decaborane (B10H14) upon the 5-hydroxytryptamine (5HT) content and the aromatic l-amino acid decarboxylase activity in rat brain was studied. Also examined was the effect of decaborane… Expand
Interaction of ethanol and thyroxine on mitochondria.
Abstract Thyroxine can stimulate mitochondrial swelling and uncouple oxidative phosphorylation. It was observed that ethanol inhibits both spontaneous and thyroxineinduced mitochrondrial swelling.… Expand
Wy‐46,300 and Wy‐46,531: Vascular Smooth Muscle Relaxant/Antihypertensive Agents with Combined Ca2+ Antagonist/Myosin Phosphorylation Inhibitory Mechanisms
- P. J. Silver, T. Sulkowski, R. Lappe, R. Wendt
- Chemistry, Medicine
- Journal of cardiovascular pharmacology
- 1 November 1986
1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-4-(pentafluorophenyl) −1,7 - naphthyridine - 3 - carboxylic acid methyl ester hydrochlorides with either a 3-phenoxy-2-hydroxypropyl (Wy-46,300) or… Expand