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Rhythmicity of RNA polymerase activity and RNA levels in nuclei of rat cerebral cortex 1
THE ACTIVITY of RNA polymerase has been measured in a variety of mammalian tissues, including nuclei of brain cells (DUTTON and MAHLER, 1968). The possibility that RNA may be involved in neuralExpand
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A semiautomated radioimmunoassay for mass screening of drugs of abuse.
A rapid, semiautomated radioimmunoassay system for detection of morphine, barbiturates, and amphetamines is described. The assays are applicable to large drug abuse screening programs. The heart ofExpand
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Some comparative biochemical effects of 5-substituted congeners of salicylic acid.
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Alterations of pineal gland biorhythms by N-methyl-3-piperidyl benzilate (JB336).
N-methyl-3-piperidyl benzilate (JB336), an anticholinergic psychotogenic agent, disrupts the circadian rhythm of serotonin in the rat pineal gland when the drug is administered at 0800 hours. TheExpand
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Antiarrhythmic, hemodynamic and cardiac electrophysiological evaluation of N-(2,6-dimethylphenyl)-N'-[3-(1-methylethylamino)propyl]urea (Wy-42,362).
The antiarrhythmic, hemodynamic and cardiac electrophysiological effects of (Wy-42,362, in the following briefly called Wy) N-(2,6-dimethylphenyl)-N'-[3-(1-methylethylamino)propyl]urea were examinedExpand
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Protection by the calcium antagonist Wy-47,037 against stress ulceration in the rat
Wy-47,037, a novel compound with both intracellular and extracellular calcium-blocking properties, was evaluated for its effects on cold/restraint stress induced ulceration in the rat. Wy-47,037Expand
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Inhibition of aromatic L-amino acid decarboxylation by decaborane.
The effect of decaborane (B10H14) upon the 5-hydroxytryptamine (5HT) content and the aromatic l-amino acid decarboxylase activity in rat brain was studied. Also examined was the effect of decaboraneExpand
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Interaction of ethanol and thyroxine on mitochondria.
Abstract Thyroxine can stimulate mitochondrial swelling and uncouple oxidative phosphorylation. It was observed that ethanol inhibits both spontaneous and thyroxineinduced mitochrondrial swelling.Expand
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Wy‐46,300 and Wy‐46,531: Vascular Smooth Muscle Relaxant/Antihypertensive Agents with Combined Ca2+ Antagonist/Myosin Phosphorylation Inhibitory Mechanisms
1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-4-(pentafluorophenyl) −1,7 - naphthyridine - 3 - carboxylic acid methyl ester hydrochlorides with either a 3-phenoxy-2-hydroxypropyl (Wy-46,300) orExpand
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2,5-benzodiazocines and intermediates.
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