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A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
TLDR
The findings suggest that QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome.
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Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats.
TLDR
It is suggested that serotonergic terminals in the striatum can convert exogenously administered L-DOPA into DA that can be released into the extracellular space.
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Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.
TLDR
Data provide direct evidence that impairment of cholesterol efflux and consequently reverse cholesterol transport is associated with reduced plasma HDL-C levels and increased risk of CAD.
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A role for neuromedin U in stress response.
TLDR
Neuromedin U that interacts anatomically and/or functionally with the CRH system is a novel physiological regulator of stress response.
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Central actions of neuromedin U via corticotropin-releasing hormone.
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Physiological roles of urocortins, human homologues of fish urotensin I, and their receptors
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Major role of 3',5'-cyclic adenosine monophosphate-dependent protein kinase A pathway in corticotropin-releasing factor gene expression in the rat hypothalamus in vivo.
TLDR
The results suggest that protein kinase A may transduce intracellular signals in CRF neurons under physiological conditions and raises the possibility that CREB may be involved in stress-induced CRF gene expression.
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[Tandospirone citrate, a selective 5-HT1A agonist, alleviates L-DOPA-induced dyskinesia in patients with Parkinson's disease].
TLDR
Tandospirone is effective in alleviating L-DOPA-induced dyskinesia in 50% of the patients, however, at the same time 50% patients showed slight worsening of parkinsonian features.
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Evaluation of diagnostic tests for ACTH-dependent Cushing's syndrome.
TLDR
The 0.5 mg dexamethasone suppression test (DST) and DDAVP test are considerably useful for the screening of ACTH-dependent Cushing's syndrome and the CRH test and 8 mg DST would be effective for the diagnosis of Cushing’s diseases when these tests are considered together.
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Regulatory mechanisms underlying corticotropin-releasing factor gene expression in the hypothalamus.
The hypothalamic-pituitary-adrenal (HPA) axis is activated under various stressors. Corticotropin-releasing factor (CRF) plays a central role in controlling stress response, and regulating the HPA…
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