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A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
- S. Takayasu, T. Sakurai, J. Sakai
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 9 May 2006
The findings suggest that QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome.
Role of serotonergic neurons in L-DOPA-derived extracellular dopamine in the striatum of 6-OHDA-lesioned rats.
- H. Tanaka, K. Kannari, T. Maeda, M. Tomiyama, T. Suda, M. Matsunaga
- Biology, ChemistryNeuroreport
- 25 February 1999
It is suggested that serotonergic terminals in the striatum can convert exogenously administered L-DOPA into DA that can be released into the extracellular space.
Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes.
- S. M. Clee, J. Kastelein, M. Hayden
- Biology, MedicineThe Journal of clinical investigation
- 15 November 2000
Data provide direct evidence that impairment of cholesterol efflux and consequently reverse cholesterol transport is associated with reduced plasma HDL-C levels and increased risk of CAD.
A role for neuromedin U in stress response.
- R. Hanada, M. Nakazato, T. Sakata
- Biology, PsychologyBiochemical and biophysical research…
- 23 November 2001
Neuromedin U that interacts anatomically and/or functionally with the CRH system is a novel physiological regulator of stress response.
Central actions of neuromedin U via corticotropin-releasing hormone.
Physiological roles of urocortins, human homologues of fish urotensin I, and their receptors
Major role of 3',5'-cyclic adenosine monophosphate-dependent protein kinase A pathway in corticotropin-releasing factor gene expression in the rat hypothalamus in vivo.
The results suggest that protein kinase A may transduce intracellular signals in CRF neurons under physiological conditions and raises the possibility that CREB may be involved in stress-induced CRF gene expression.
[Tandospirone citrate, a selective 5-HT1A agonist, alleviates L-DOPA-induced dyskinesia in patients with Parkinson's disease].
- K. Kannari, K. Kurahashi, M. Matsunaga
- Psychology, MedicineNo to shinkei = Brain and nerve
- 1 February 2002
Tandospirone is effective in alleviating L-DOPA-induced dyskinesia in 50% of the patients, however, at the same time 50% patients showed slight worsening of parkinsonian features.
Evaluation of diagnostic tests for ACTH-dependent Cushing's syndrome.
The 0.5 mg dexamethasone suppression test (DST) and DDAVP test are considerably useful for the screening of ACTH-dependent Cushing's syndrome and the CRH test and 8 mg DST would be effective for the diagnosis of Cushing’s diseases when these tests are considered together.
Regulatory mechanisms underlying corticotropin-releasing factor gene expression in the hypothalamus.
The hypothalamic-pituitary-adrenal (HPA) axis is activated under various stressors. Corticotropin-releasing factor (CRF) plays a central role in controlling stress response, and regulating the HPA…