Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.
- H. Yasuda, N. Shima, T. Suda
- Biology, MedicineProceedings of the National Academy of Sciences…
- 31 March 1998
A genetically engineered soluble form containing the extracellular domain of the protein induced OCL formation from spleen cells in the absence of osteoblasts/stromal cells, and it was concluded that the membrane-bound protein is osteoclast differentiation factor (ODF), a long-sought ligand mediating an essential signal to osteOClast progenitors for their differentiation into osteoclasts.
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families.
- T. Suda, N. Takahashi, N. Udagawa, E. Jimi, M. Gillespie, T. Martin
- Biology, MedicineEndocrine reviews
- 1 June 1999
Osteoblasts/stromal cells can now be replaced with RANKL and M-CSF in dealing with the whole life of osteoclasts, and new ways to treat several metabolic bone diseases caused by abnormal osteoclast recruitment and functions will be established.
IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis.
- S. Kotake, N. Udagawa, T. Suda
- Biology, MedicineJournal of Clinical Investigation
- 1 May 1999
It is suggested that IL-17 first acts on osteoblasts, which stimulates both COX-2-dependent PGE2 synthesis and ODF gene expression, which in turn induce differentiation of osteoclast progenitors into mature osteoclasts, and that IL -17 is a crucial cytokine for osteoclastic bone resorption in RA patients.
Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction
- Kanichiro Kobayashi, N. Takahashi, T. Suda
- Biology, MedicineJournal of Experimental Medicine
- 17 January 2000
It is demonstrated that TNF-α stimulates osteoclast differentiation in the presence of M-CSF through a mechanism independent of the ODF/RANKL–RANK system.
Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.
- N. Udagawa, N. Takahashi, T. Suda
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 September 1990
The results indicate that osteoclasts are also derived from the mature monocytes and macrophages when a suitable microenvironment is provided by bone marrow-derived stromal cells.
The role of prostaglandin E receptor subtypes (EP1, EP2, EP3, and EP4) in bone resorption: an analysis using specific agonists for the respective EPs.
- T. Suzawa, C. Miyaura, T. Suda
- Biology, MedicineEndocrinology
- 1 April 2000
It is suggested that PGE2 stimulates bone resorption by a mechanism involving cAMP and ODF, which is mediated mainly by EP4 and partially by EP2, while the involvement of PGE receptor subtypes, EP1,EP2, EP3, and EP4, in PGM using specific agonists for the respective EPs is examined.
Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1.
- A. Yamaguchi, T. Komori, T. Suda
- BiologyEndocrine reviews
- 1 August 2000
Osteoblasts arise from common progenitors with chondrocytes, muscle and adipocytes, and various hormones and local factors regulate their differentiation. We review here regulation of osteoblast…
Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells.
- T. Ishizuya, S. Yokose, A. Yamaguchi
- Biology, MedicineJournal of Clinical Investigation
- 15 June 1997
The results suggest that PTH has diverse effects on osteoblast differentiation depending on the exposure time in vitro mediated through different signal transduction systems, and at least in part the in vivo action of PTH that varies with the mode of administration.
Modulation of osteoclast differentiation.
- T. Suda, N. Takahashi, T. Martin
- Biology, MedicineEndocrine reviews
- 1 February 1992
Osteotropic hormones such as 1α, 25-dihydroxyvitamin D3 [1α,25(OH)2D3], PTH, and calcitonin preferentially modulate the process of bone resorption to maintain bone remodeling.
Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]
- T. Katagiri, A. Yamaguchi, T. Suda
- Biology, MedicineJournal of Cell Biology
- 2 December 1994
Results indicate that BMP-2 specifically converts the differentiation pathway of C2C12 myoblasts into that of osteoblast lineage cells, but that the conversion is not heritable.
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