• Publications
  • Influence
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.
TLDR
The results reveal that the orchestrated ER chaperone machinery at MAM, by sensing ER Ca(2+) concentrations, regulates ER-mitochondrial interorganellar Ca( 2+) signaling and cell survival. Expand
Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival
TLDR
The results reveal that the orchestrated ER chaperone machinery at MAM, by sensing ER Ca(2+) concentrations, regulates ER-mitochondrial interorganellar Ca( 2+) signaling and cell survival. Expand
Time-Dependent Increases in Brain-Derived Neurotrophic Factor Protein Levels within the Mesolimbic Dopamine System after Withdrawal from Cocaine: Implications for Incubation of Cocaine Craving
TLDR
Time-dependent increases in BDNF levels may lead to synaptic modifications that underlie enhanced responsiveness to cocaine cues after prolonged withdrawal periods, and these changes were observed during tests for sucrose craving. Expand
MAM: more than just a housekeeper.
The physical association between the endoplasmic reticulum (ER) and mitochondria, which is known as the mitochondria-associated ER membrane (MAM), has important roles in various cellularExpand
The sigma-1 receptor chaperone as an inter-organelle signaling modulator.
TLDR
The sigma-1 receptor (Sig-1R), an ER chaperone protein, acts as an inter-organelle signaling modulator locally at the MAM and remotely at the plasmalemma/plasma membrane. Expand
The pharmacology of sigma-1 receptors.
  • T. Maurice, T. Su
  • Chemistry, Medicine
  • Pharmacology & therapeutics
  • 1 November 2009
TLDR
It is found that the most prominent action of sigma-1 receptors in biological systems including cell lines, primary cultures, and animals is the regulation and modulation of voltage-regulated and ligand-gated ion channels, including Ca(2-)-, K(+)-, Na(+), Cl(-), and SK channels, and NMDA and IP3 receptors. Expand
A proposal for the classification of sigma binding sites.
Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems.
TLDR
The findings suggest that steroids are naturally occurring ligands for sigma receptors and raise the possibility that these sites mediate some aspects of steroid-induced mental disturbances and alterations in immune functions. Expand
Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival
TLDR
The ER-mitochondrion interface serves as an important subcellular entity in the regulation of cellular survival by enhancing the stress-responding signaling between mitochondria, ER, and nucleus. Expand
Dynamic Interaction between Sigma-1 Receptor and Kv1.2 Shapes Neuronal and Behavioral Responses to Cocaine
TLDR
It is found that cocaine exposure triggers a Sig-1R-dependent upregulation of D-type K(+) current in the nucleus accumbens (NAc) that results in neuronal hypoactivity and thereby enhances behavioral cocaine response. Expand
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