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Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.
TLDR
The results reveal that the orchestrated ER chaperone machinery at MAM, by sensing ER Ca(2+) concentrations, regulates ER-mitochondrial interorganellar Ca( 2+) signaling and cell survival.
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Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival
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Time-Dependent Increases in Brain-Derived Neurotrophic Factor Protein Levels within the Mesolimbic Dopamine System after Withdrawal from Cocaine: Implications for Incubation of Cocaine Craving
TLDR
Time-dependent increases in BDNF levels may lead to synaptic modifications that underlie enhanced responsiveness to cocaine cues after prolonged withdrawal periods, and these changes were observed during tests for sucrose craving.
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MAM: more than just a housekeeper.
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The sigma-1 receptor chaperone as an inter-organelle signaling modulator.
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The pharmacology of sigma-1 receptors.
  • T. Maurice, T. Su
  • Biology, Medicine
    Pharmacology & therapeutics
  • 1 November 2009
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Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems.
TLDR
The findings suggest that steroids are naturally occurring ligands for sigma receptors and raise the possibility that these sites mediate some aspects of steroid-induced mental disturbances and alterations in immune functions.
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A proposal for the classification of sigma binding sites.
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Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival
TLDR
The ER-mitochondrion interface serves as an important subcellular entity in the regulation of cellular survival by enhancing the stress-responding signaling between mitochondria, ER, and nucleus.
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The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems.
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