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Role of the p53-homologue p73 in E2F1-induced apoptosis
Most human cancers harbour aberrations of cell-cycle control, which result in deregulated activity of the E2F transcription factors with concomitant enhanced cell-cycle progression. Oncogenic… Expand
p53 family members in myogenic differentiation and rhabdomyosarcoma development.
The p53 family comprises the tumor suppressor p53 and the structural homologs p63 and p73. How the three family members cooperate in tumor suppression remains unclear. Here, we report different but… Expand
Transactivation-deficient Delta TA-p73 inhibits p53 by direct competition for DNA binding: implications for tumorigenesis.
- T. Stiewe, C. Theseling, B. Pützer
- Biology, Medicine
- The Journal of biological chemistry
- 19 April 2002
The p53 family member p73 displays significant structural and functional homology to p53. However, instead of mutational inactivation, overexpression of wild-type p73 has been reported in various… Expand
C-terminal diversity within the p53 family accounts for differences in DNA binding and transcriptional activity
The p53 family is known as a family of transcription factors with functions in tumor suppression and development. Whereas the central DNA-binding domain is highly conserved among the three family… Expand
The p53 family in differentiation and tumorigenesis
- T. Stiewe
- Biology, Medicine
- Nature Reviews Cancer
- 1 March 2007
The role of p53 as a tumour suppressor is generally attributed to its ability to stop the proliferation of precancerous cells by inducing cell-cycle arrest or apoptosis. The relatives and… Expand
Transactivation-deficient DeltaTA-p73 acts as an oncogene.
The recently discovered p53-family member p73 displays significant homology to p53, but data from primary tumors and knockout mice argue against p73 being a classical tumor suppressor. We report on… Expand
A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.
Senescence, perceived as a cancer barrier, is paradoxically associated with inflammation, which promotes tumorigenesis. Here, we characterize a distinct low-grade inflammatory process in stressed… Expand
Role of p73 in malignancy: tumor suppressor or oncogene?
The recently identified p53 family member, p73, shows substantial structural and functional homology with p53. However, despite the established role of p53 as a proto-type tumor suppressor, a similar… Expand
Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions
p53 protects us from cancer by transcriptionally regulating tumor suppressive programs designed to either prevent the development or clonal expansion of malignant cells. How p53 selects target genes… Expand
SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
Endogenous retroviruses (ERVs) can confer benefits to their host but present a threat to genome integrity if not regulated correctly. Here we identify the SWI/SNF-like remodeler SMARCAD1 as a key… Expand