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Neuropathological Classification of Huntington's Disease
In postmortem brain specimens from 163 clinically diagnosed cases of Huntington's disease (HD) the striatum exhibited marked variation in the severity of neuropathological involvement. A system forExpand
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Decreased Neuronal and Increased Oligodendroglial Densities in Huntington's Disease Caudate Nucleus
Decreased density of neurons was found throughout the head of the caudate nucleus in Huntington's disease (HD), with the most severe neuronal loss early in the disease in the medial region. TheExpand
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The role of water in opal
Abstract The occurrence of water in natural opaline silicas has been studied by differential thermal analysis, thermogravimetric analysis, infra‐red analysis and nuclear magnetic resonance. TheExpand
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Clinical and neuropathologic assessment of severity in Huntington's disease
Clinical records were evaluated for 163 Huntington's disease patients in whom postmortem brain specimens had been graded for degree of neuropathologic involvement in the striatum. Juvenile/adolescentExpand
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Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
We have demonstrated previously that noncoding sequences of genes are a robust source of polymorphisms between mouse species when tested using single-strand conformation polymorphism (SSCP) analysis,Expand
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Lipid metabolism in mucous-dwelling amitochondriate protozoa.
Entamoeba, Giardia, and trichomonads are the prominent members of a group known as 'mucosal parasites'. While Entamoeba and Giardia trophozoites colonise the small intestine, trichomonads inhabit theExpand
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Single pass sequencing and physical and genetic mapping of human brain cDNAs
We have performed single pass sequencing of 1,024 human brain cDNAs, over 900 of which seem to represent new human genes. Library prescreening with total brain cDNA significantly reduced repeatedExpand
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Phospholipid remodeling/generation in Giardia: the role of the Lands cycle.
Recent results suggest that Giardia is able to carry out deacylation/reacylation reactions (the Lands cycle) to generate new phospholipids, effectively bypassing the de novo synthesis of the entireExpand
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Gene–based sequence–tagged–sites (STSs) as the basis for a human gene map
Using our data set of 3,143 single pass sequences from human brain cDNA libraries, we have developed a strategy in which gene–based sequence–tagged–sites (STSs), derived from 3′untranslated regionsExpand
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