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Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol.
The abundance of cell cholesterol is governed by multiple regulatory proteins in the endoplasmic reticulum (ER) which, in turn, are under the control of the cholesterol in that organelle. But how… Expand
Cholesterol Movement in Niemann-Pick Type C Cells and in Cells Treated with Amphiphiles*
Cholesterol accumulates to massive levels in cells from Niemann-Pick type C (NP-C) patients and in cells treated with class 2 amphiphiles that mimic NP-C disease. This behavior has been attributed to… Expand
Cyclic 3', 5'-AMP relay dictyostelium discoideum. V. Adaptation of the cAMP signaling response during cAMP stimulation
In dictyostelium discoideum, extracellular cAMP activates adenylate cyclase, which leads to an increase in intracellular cAMP and the rate of cAMP secretion. The signaling response to a constant cAMP… Expand
Plasma membranes contain half the phospholipid and 90% of the cholesterol and sphingomyelin in cultured human fibroblasts.
- Y. Lange, M. Swaisgood, B. Ramos, T. Steck
- Biology, Medicine
- The Journal of biological chemistry
- 5 March 1989
The literature suggests that cholesterol and sphingomyelin might be essentially confined to plasma membranes in mammalian cells; however, this premise has thus far escaped a direct test. We explored… Expand
Cyclic 3', 5'-AMP relay in dictyostelium discoideum. IV. Recovery of the cAMP signaling response after adaptation to cAMP
In dictyoselium discoideum, an increase in extracellular cAMP activates adenylate cyclase, leading to an increase in intracellular cAMP and the rate of cAMP secretion. Cells adapt to any constant… Expand
Quantitation of the Pool of Cholesterol Associated with Acyl-CoA:Cholesterol Acyltransferase in Human Fibroblasts*
The esterification of cholesterol in homogenates of human fibroblasts was explored as a means of estimating the size of the pool of cholesterol associated with the endoplasmic reticulum (ER)in vivo.… Expand
Cholesterol homeostasis. Modulation by amphiphiles.
Diverse amphiphiles act on cellular cholesterol metabolism as if signaling regulatory sites. One class (oxysterols) mimics the homeostatic effects of excess cell cholesterol, inhibiting cholesterol… Expand
Circulation of Cholesterol between Lysosomes and the Plasma Membrane*
The cholesterol in the lysosomes of cultured human fibroblasts was determined to constitute ∼6% of the cell total. This pool was enlarged by as much as 10-fold in Niemann-Pick type C cells. Certain… Expand
The uptake of nucleosides by cells in culture. I. Inhibition by heterologous nucleosides.
Abstract Millimolar levels of nucleosides inhibited the uptake of trace levels of other, labeled nucleosides into the RNA and DNA of chicken, rat and mouse cells in culture. The incorporation of… Expand
Role of the reticulum in the stability and shape of the isolated human erythrocyte membrane
In order to examine the widely held hypothesis that the reticulum of proteins which covers the cytoplamsic surface of the human erythrocyte membrane controls cell stability and shape, we have… Expand