Author pages are created from data sourced from our academic publisher partnerships and public sources.
Share This Author
Identification of the von Hippel-Lindau disease tumor suppressor gene.
A gene discovered by positional cloning has been identified as the von Hippel-Lindau (VHL) disease tumor suppressor gene. A restriction fragment encompassing the gene showed rearrangements in 28 of… Expand
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumours1–4. The… Expand
Germline mutations in the von Hippel–Lindau disease tumor suppressor gene: Correlations with phenotype
Von Hippel‐Lindau disease (VHL) is an inherited neoplastic disease characterized by a predisposition to develop retinal angiomas, central nervous system hemangioblastomas, renal cell carcinomas,… Expand
Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations.
- T. Kishida, T. Stackhouse, F. Chen, M. Lerman, B. Zbar
- Biology, Medicine
- Cancer research
- 15 October 1995
The von Hippel-Lindau disease (VHL) gene is a novel tumor suppressor gene that plays a role in the pathogenesis of renal cell carcinomas and hemangioblastomas of the central nervous system. To begin… Expand
cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein.
cDNA clones having extensive sequence identity with the sea urchin fascin and the Drosophila singed gene products were isolated from a human teratocarcinoma cDNA library. The human homolog, termed… Expand
Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma.
Effects of the phenylalanine-22----leucine, glutamic acid-49----methionine, glycine-234----aspartic acid, and glycine-234----lysine mutations on the folding and stability of the alpha subunit of…
- A. Beasty, M. Hurle, J. Manz, T. Stackhouse, J. Onuffer, C. Matthews
- Chemistry, Medicine
- 20 May 1986
The effects of four single amino acid replacements on the stability and folding of the alpha subunit of tryptophan synthase from Escherichia coli have been investigated by ultraviolet differences… Expand
Alterations in T-lymphocyte subpopulations in patients with head and neck cancer. Correlations with prognosis.
- G. Wolf, S. Schmaltz, +5 authors K. Mcclatchey
- Archives of otolaryngology--head & neck surgery
- 1 November 1987
Impaired cell-mediated immunity has been consistently demonstrated in patients with advanced head and neck squamous cancer (HNSC); however, the results of prior studies of correlations of cellular… Expand
Expression of the Von Hippel-Lindau Tumor Suppressor Gene, VHL, in Human Fetal Kidney and During Mouse Embryogenesis
BackgroundVon Hippel-Lindau (VHL) disease is a familial cancer syndrome that has a dominant inherited pattern which predisposes affected individuals to a variety of tumors. The most frequent tumors… Expand
Expression of von Hippel–Lindau Protein in Normal and Pathological Human Tissues
- N. Sakashita, M. Takeya, T. Kishida, T. Stackhouse, B. Zbar, Kiyoshi Takahashi
- Biology, Medicine
- The Histochemical Journal
- 6 July 1999
To examine the localization of von Hippel–Lindau (VHL) protein in human tissues, we produced four novel monoclonal antibodies against human VHL protein. Western blot analysis revealed that two of… Expand