T. Sprinkle

Publications43
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Citations1,674
Highly Influential Citations37
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2',3'-cyclic nucleotide 3'-phosphodiesterase, an oligodendrocyte-Schwann cell and myelin-associated enzyme of the nervous system.
  • T. Sprinkle
  • Biology, Chemistry
    Critical reviews in neurobiology
  • 1989
TLDR
The absolute hydrolysis specificity, yielding 2'-mononucleotides from 2',3'-cyclic substrates, strongly suggests that CNPase is a nucleic acid enzyme, possibly related to RNA metabolism.
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Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions.
TLDR
The finding of large numbers of immature oligodendrocytes, presumably expressing many developmentally restricted antigens not normally present in the mature nervous system, in plaques at a particular stage in their evolution may be important in understanding why remyelination eventually fails in multiple sclerosis.
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A pathology-MRI study of the short-T2 component in formalin-fixed multiple sclerosis brain
TLDR
Evidence indicates that the short-T2 (10 to 50 millisecond) component of the T2 relaxation distribution originates from water in myelin sheaths in patients with MS, and supports the hypothesis that the long-T1 component originatesfrom water related to myelin.
View on Wolters Kluwer
Monoclonal antibody production to human and bovine 2′:3′-cyclic nucleotide 3′-phosphodiesterase (CNPase): high-specificity recognition in whole brain acetone powders and conservation of sequence…
View on Elsevier
Differential expression of galactocerebroside, myelin basic protein, and 2′,3′‐cyclic nucleotide 3′‐phosphohydrolase during development of oligodendrocytes in vitro
TLDR
The differential expression and localization of myelin components within membrane sheets produced by oligodendrocytes in vitro is described and GC and myelin basic protein (MBP) staining are seen in similar membrane domains even though GC is a surface component while MBP resides on the cytoplasmic face.
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Isolation of a cDNA encoding a taurine transporter in the human retinal pigment epithelium.
TLDR
The results suggest that the PCR product encodes a functional taurine transporter whose characteristics are similar to those of t aurine uptake observed in the original HRPE cells.
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Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors.
TLDR
It is suggested that phosphorylation/dephosphorylation of myelin basic protein and 2',3'-cyclic nucleotide 2'-phosphodiesterase may be key processes in the cascade of events that are initiated by adhesion of OLG to a polylysine surface (possibly acting as a surrogate for axons) and culminate in the reformation ofMyelin.
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Assignment of the membrane-bound human aminopeptidase P gene (XPNPEP2) to chromosome Xq25.
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ACTIVITY OF 2′,3′‐CYCLIC‐NUCLEOTIDE 3′‐PHOSPHODIESTERASE IN REGIONS OF RAT BRAIN DURING DEVELOPMENT: QUANTITATIVE RELATIONSHIP TO MYELIN BASIC PROTEIN
TLDR
The developmental profile of the enzyme appeared to correlate with the onset of myelination and with the levels of myelin basic protein as well as the appearance of galactocerebroside sulfotransferase.
View on Wiley
Purification of Rat 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase
TLDR
The amino acid analysis of the purified rat enzyme compared favorably with reported determinations for the bovine enzyme and also with reported values for the rat Wolfgram proteins W1 and W2.
View on Wiley
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